Evidence map›Paper›PMID 38902301›Full record

ArticleScientific reports2024

Reduced graphene oxide/zinc oxide composite as an electrochemical sensor for acetylcholine detection.

Siraprapa Pitiphattharabun, Krittin Auewattanapun, Thura Lin Htet, Myo Myo Thu, Gasidit Panomsuwan, Ratchatee Techapiesancharoenkij, Jun Ohta, Oratai Jongprateep

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  10. Flexible, self-standing 3D NbMikrochimica acta · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siraprapa PitiphattharabunDepartment of Materials Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand.
Krittin AuewattanapunDepartment of Materials Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand.
Thura Lin HtetDepartment of Materials Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand.
Myo Myo ThuDepartment of Materials Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand.
Gasidit PanomsuwanDepartment of Materials Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand.
Ratchatee TechapiesancharoenkijDepartment of Materials Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand.
Jun OhtaInternational Collaborative Education Program for Materials Technology, Education, and Research (ICE-Matter), ASEAN University Network/Southeast Asia Engineering Education Development Network (AUN/SEED-Net), Bangkok, Thailand.
Oratai JongprateepDepartment of Materials Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand. fengotj@ku.ac.th.

Funding

Kasetsart University Research and Development Institute FF(KU) 25.64
6 · The paper itself

Abstract

Acetylcholine (ACh) plays a pivotal role as a neurotransmitter, influencing nerve cell communication and overall nervous system health. Imbalances in ACh levels are linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. This study focused on developing electrochemical sensors for ACh detection, utilizing graphene oxide (GO) and a composite of reduced graphene oxide and zinc oxide (rGO/ZnO). The synthesis involved modified Hummers' and hydrothermal methods, unveiling the formation of rGO through deoxygenation and the integration of nano-sized ZnO particles onto rGO, as demonstrated by XPS and TEM. EIS analysis also revealed the enhancement of electron transfer efficiency in rGO/ZnO. Cyclic voltammograms of the electrode, comprising the rGO/ZnO composite in ACh solutions, demonstrated prominent oxidation and reduction reactions. Notably, the composite exhibited promise for ACh detection due to its sensitivity, low detection threshold, reusability, and selectivity against interfering compounds, specifically glutamate and gamma-aminobutyric acid. The unique properties of rGO, such as high specific surface area and electron mobility, coupled with ZnO's stability and catalytic efficiency, contributed to the composite's potential in electrochemical sensor applications. This research, emphasizing the synthesis, fabrication, and characterization of the rGO/ZnO composite, established itself as a reliable platform for detecting the acetylcholine neurotransmitter.

Indexed as

AcetylcholineElectrochemical TechniquesGraphiteOxidation-ReductionZinc OxideBiosensing TechniquesElectrodesHumansAcetylcholinegraphene oxideGraphiteZinc OxideAcetylcholineElectrocatalytic activityReduced graphene oxideSensorZinc oxide

Identifiers

PMID38902301
PMCPMC11190213

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.