Evidence map›Paper›PMID 38902236›Full record

ArticleNature communications2024

BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network.

Romain Beaubois, Jérémy Cheslet, Tomoya Duenki, Giuseppe De Venuto, Marta Carè, Farad Khoyratee, Michela Chiappalone, Pascal Branchereau, Yoshiho Ikeuchi, Timothée Levi

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Fabrication of High-Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Online supervised learning of temporal patterns in biological neural networks under feedback control.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Romain BeauboisIMS, CNRS UMR5218, Bordeaux INP, University of Bordeaux, Talence, France.ORCID http://orcid.org/0009-0002-3396-6058
Jérémy ChesletIMS, CNRS UMR5218, Bordeaux INP, University of Bordeaux, Talence, France.ORCID http://orcid.org/0009-0005-3284-320X
Tomoya DuenkiInstitute of Industrial Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5570-7220
Giuseppe De VenutoDIBRIS, University of Genova, Genova, Italy.
Marta CarèDIBRIS, University of Genova, Genova, Italy.ORCID http://orcid.org/0000-0002-7100-1639
Farad KhoyrateeIMS, CNRS UMR5218, Bordeaux INP, University of Bordeaux, Talence, France.
Michela ChiappaloneDIBRIS, University of Genova, Genova, Italy.ORCID http://orcid.org/0000-0003-1427-5147
Pascal BranchereauINCIA, UMR5287, CNRS, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0003-3972-8229
Yoshiho IkeuchiInstitute of Industrial Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2829-3840
Timothée LeviIMS, CNRS UMR5218, Bordeaux INP, University of Bordeaux, Talence, France. timothee.levi@u-bordeaux.fr.ORCID http://orcid.org/0000-0003-0378-8529

Funding

Université de Bordeaux (University of Bordeaux) Idex International
6 · The paper itself

Abstract

Characterization and modeling of biological neural networks has emerged as a field driving significant advancements in our understanding of brain function and related pathologies. As of today, pharmacological treatments for neurological disorders remain limited, pushing the exploration of promising alternative approaches such as electroceutics. Recent research in bioelectronics and neuromorphic engineering have fostered the development of the new generation of neuroprostheses for brain repair. However, achieving their full potential necessitates a deeper understanding of biohybrid interaction. In this study, we present a novel real-time, biomimetic, cost-effective and user-friendly neural network capable of real-time emulation for biohybrid experiments. Our system facilitates the investigation and replication of biophysically detailed neural network dynamics while prioritizing cost-efficiency, flexibility and ease of use. We showcase the feasibility of conducting biohybrid experiments using standard biophysical interfaces and a variety of biological cells as well as real-time emulation of diverse network configurations. We envision our system as a crucial step towards the development of neuromorphic-based neuroprostheses for bioelectrical therapeutics, enabling seamless communication with biological networks on a comparable timescale. Its embedded real-time functionality enhances practicality and accessibility, amplifying its potential for real-world applications in biohybrid experiments.

Indexed as

BiomimeticsNervous System DiseasesNeural Networks, ComputerAction PotentialsAnimalsHumansModels, NeurologicalNerve NetNeurons

Identifiers

PMID38902236
PMCPMC11190274

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.