Evidence map›Paper›PMID 38902031›Full record

ArticleOccupational and environmental medicine2024

Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study.

Inge Brosbøl Iversen, Jesper Medom Vestergaard, Johan Ohlander, Susan Peters, Elisabeth Bendstrup, Jens Peter Ellekilde Bonde, Vivi Schlünssen, Jakob Hjort Bønløkke, Finn Rasmussen, Zara Ann Stokholm and 3 more

Abstract read
In one paragraph

Article in Occupational and environmental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Particles exposures and sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  6. The Role of Particle Inhalation in Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Inge Brosbøl IversenDepartment of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark iniver@rm.dk.ORCID 0009-0008-0064-4822
Jesper Medom VestergaardDepartment of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark.
Johan OhlanderInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-4279-2563
Susan PetersInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-5662-1971
Elisabeth BendstrupCenter for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
Jens Peter Ellekilde BondeDepartment of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.ORCID 0000-0002-8181-3673
Vivi SchlünssenDepartment of Public Health, Research Unit for Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
Jakob Hjort BønløkkeDepartment of Occupational and Environmental Medicine, Danish Ramazzini Centre, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0002-8247-6576
Finn RasmussenDepartment of Radiology, Aarhus University Hospital, Aarhus, Denmark.
Zara Ann StokholmDepartment of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark.
Michael Brun AndersenDepartment of Radiology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark.
Hans KromhoutInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-4233-1890
Henrik Albert KolstadDepartment of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespirable crystalline silica is a well-known cause of silicosis but may also be associated with other types of interstitial lung disease. We examined the associations between occupational exposure to respirable crystalline silica and the risk of idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis.

methodsThe total Danish working population was followed 1977-2015. Annual individual exposure to respirable crystalline silica was estimated using a quantitative job exposure matrix. Cases were identified in the Danish National Patient Register. We conducted adjusted analyses of exposure-response relations between cumulative silica exposure and other exposure metrics and idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis.

resultsMean cumulative exposure was 125 µg/m

conclusionThis study suggests that silica inhalation may be related to pulmonary sarcoidosis and idiopathic interstitial pneumonias, though these findings may to some extent be explained by diagnostic misclassification. The observed exposure-response relations for silicosis at lower cumulative exposure levels than previously reported need to be corroborated in analyses that address the limitations of this study.

Indexed as

Idiopathic Interstitial PneumoniasOccupational DiseasesOccupational ExposureSarcoidosis, PulmonarySilicon DioxideSilicosisAdultAgedDenmarkFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedProspective StudiesSilicon DioxideLung Diseases, InterstitialOccupational HealthSilicosis

Identifiers

PMID38902031
PMCPMC11287551

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.