Evidence map›Paper›PMID 38901960›Full record

Trial reportThe British journal of ophthalmology2024

Pros and cons of internal limiting membrane peeling during epiretinal membrane surgery: a randomised clinical trial with microperimetry (PEELING).

Jean-Baptiste Ducloyer, Yannick Eude, Christelle Volteau, Olivier Lebreton, Alexandre Bonissent, Paul Fossum, Ramin Tadayoni, Catherine P Creuzot-Garcher, Yannick Le Mer, Julien Perol and 7 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02146144 (Prospective, Randomized, Controlled and Single-blind Study Assessing the Benefit/Risk Ratio of Internal Limiting Membrane), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02146144 nacompletednot on this map

Prospective, Randomized, Controlled and Single-blind Study Assessing the Benefit/Risk Ratio of Internal Limiting Membrane (ILM) Peeling During Epimacular Membrane (EMM) Surgery

TypeinterventionalSponsorNantes University HospitalRan2014 to 2022Enrolled213ConditionsIdiopathic Epimacular MembraneArmsILM Peeling
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Sonography versus anterior segment OCT for imaging bleb morphology after glaucoma drainage device surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Article
  4. Metamorphopsia after surgery for rhegmatogenous retinal detachment.International journal of ophthalmology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jean-Baptiste DucloyerCHU Nantes Department of Ophthalmology, Nantes University, Nantes, France jeanbaptiste.ducloyer@chu-nantes.fr.ORCID http://orcid.org/0000-0002-1306-1908
Yannick EudeCHU Nantes Department of Ophthalmology, Nantes University, Nantes, France.
Christelle VolteauCHU Nantes, Sponsor Departement, Nantes University, Nantes, Pays de la Loire, France.
Olivier LebretonCHU Nantes Department of Ophthalmology, Nantes University, Nantes, France.
Alexandre BonissentCHU Nantes Department of Ophthalmology, Nantes University, Nantes, France.
Paul FossumCHU Nantes Department of Ophthalmology, Nantes University, Nantes, France.
Ramin TadayoniOphthalmology department, Hoital Lariboisière, AP-HP, Université paris 7 - Sorbonne Paris Cité, Paris, France.
Catherine P Creuzot-GarcherOphthalmology, CHU Dijon, Dijon, Bourgogne-Franche-Comté, France.
Yannick Le MerFondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Julien PerolOphthalmology Department, Polyclinique de l'Atlantique, Saint Herblain, France.
June FortinCHU Nantes, Sponsor Departement, Nantes University, Nantes, Pays de la Loire, France.
Alexandra JobertCHU Nantes, Sponsor Departement, Nantes University, Nantes, Pays de la Loire, France.
Fanny BillaudCHU Nantes Department of Ophthalmology, Nantes University, Nantes, France.
Catherine IvanCHU Nantes Department of Ophthalmology, Nantes University, Nantes, France.
Alexandra PoinasInserm, CIC 1413, CHU Nantes, Nantes, Pays de la Loire, France.
Michel WeberCHU Nantes Department of Ophthalmology, Nantes University, Nantes, France.
CFSR Research Net

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAfter idiopathic epiretinal membrane (iERM) removal, it is unclear whether the internal limiting membrane (ILM) should be removed. The objective was to assess if active ILM peeling after iERM removal could induce microscotomas.

methodsThe PEELING study is a national randomised clinical trial. When no spontaneous ILM peeling occurred, patients were randomised either to the ILM peeling or no ILM peeling group. Groups were compared at the month 1 (M1), M6 and M12 visits in terms of microperimetry, best-corrected visual acuity (BCVA) and optical coherence tomography findings. The primary outcome was the difference in microscotoma number between baseline and M6.

results213 patients were included, 101 experienced spontaneous ILM peeling and 100 were randomised to the ILM peeling (n=51) or no ILM peeling group (n=49). The difference in microscotoma number between both groups was significant at M1 (3.9 more microscotomas in ILM peeling group, (0.8;7.0) p=0.0155) but not at M6 (2.1 more microscotomas in ILM peeling group (-0.5;4.7) p=0.1155). Only in the no ILM peeling group, the number of microscotomas significantly decreased and the mean retinal sensitivity significantly improved. The ERM recurred in nine patients in the no ILM peeling group (19.6%) versus zero in the ILM peeling group (p=0.0008): two of them underwent revision surgery. There was no difference in mean BCVA and microperimetry between patients experiencing or not a recurrence at M12.

conclusionSpontaneous ILM peeling is very common. Active ILM peeling prevents anatomical ERM recurrence but may induce retinal impairments and delay visual recovery.

trial registrationNCT02146144.

Indexed as

Basement MembraneEpiretinal MembraneTomography, Optical CoherenceVisual AcuityVisual FieldsVisual Field TestsVitrectomyAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedMaculaProspective StudiesRetinaTreatment Surgery

Identifiers

PMID38901960
PMCPMC11672040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.