Evidence map›Paper›PMID 38901946›Full record

ArticleClinical nutrition ESPEN2024

Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial.

Hassan S Dashti, Magdalena Sevilla-Gonzalez, Kris M Mogensen, Marion F Winkler, Charlene Compher

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical nutrition ESPEN, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04743960 (Assessing Metabolic and Sleep Consequences of Overnight Home Parenteral Nutrition), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04743960 nacompletednot on this map

Assessing Metabolic and Sleep Consequences of Overnight Home Parenteral Nutrition

TypeinterventionalSponsorMassachusetts General HospitalRan2021 to 2022Enrolled20ConditionsFeeding Patterns, Sleep, Glucose Intolerance, Short Bowel SyndromeArmsTime-of-day of parenteral nutrition provision
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hassan S DashtiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Division of Nutrition, Harvard Medical School, Boston, MA, USA; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of M.I.T and Harvard, Cambridge, MA, USA. Electronic address: hassan.dashti@mgh.harvard.edu.
Magdalena Sevilla-GonzalezPrograms in Metabolism and Medical & Population Genetics, The Broad Institute of M.I.T and Harvard, Cambridge, MA, USA; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Kris M MogensenDepartment of Nutrition, Brigham and Women's Hospital, Boston, MA, USA.
Marion F WinklerDepartment of Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
Charlene CompherBiobehavioral Health Sciences Department, University of Pennsylvania School of Nursing, Philadelphia, PA, USA.

Funding

The impact of overnight nutrition support on sleep and circadian rhythm disruption in the ICUR00HL153795 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DASHTI, HASSAN S. · 2023 to 2025
$747k
NHLBI NIH HHS R00 HL153795
6 · The paper itself

Abstract

backgroundHome parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight.

methodsThis secondary analysis leveraged samples from a clinical trial in adults with short bowel syndrome consuming HPN (ClinicalTrials.gov: NCT04743960). Enrolled patients received 1 week of HPN overnight followed by 1 week of HPN during the daytime. Fasting blood samples were collected following each study period and global metabolic profiles were examined from plasma samples. Differential metabolite abundance was determined from normalized and scaled data using adjusted Linear Models for MicroArray Data models followed by pathway enrichment analysis.

resultsNine patients (mean age, 52.6 years; 78% female; mean BMI 20.7 kg/m

conclusionDaytime infusions of HPN may result in changes in circulating lipids and amino acid composing metabolic pathways previously implicated in circadian rhythms. As this is the first untargeted metabolomics study of HPN, larger studies are needed.

Indexed as

MetabolomicsParenteral Nutrition, HomeShort Bowel SyndromeAdultCircadian RhythmFemaleHumansMaleMiddle AgedChronobiologyCircadian rhythmsHome parenteral nutritionMetabolomicsNutrition

Identifiers

PMID38901946
PMCPMC11190456

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.