Evidence map›Paper›PMID 38901617›Full record

ArticleThe journal of allergy and clinical immunology. In practice2024

A novel splice-site mutation in NFKB1 presenting as common variable immunodeficiency and postoperative hyperinflammation responsive to anti-IL-1 therapy.

Taylor Eddens, Jennifer Lue, Jorna Sojati, Michael Tomani, Ozgur Dede, Kate Kernan, Daniel Kietz, Allyson Larkin, Hey Chong, Kara Coffey

Abstract readCase Reports
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taylor EddensDivision of Allergy/Immunology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Jennifer LueDivision of Allergy/Immunology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Jorna SojatiUniversity of Pittsburgh Medical Scientist Training Program, Pittsburgh, Pa.
Michael TomaniDivision of Rheumatology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Ozgur DedeDepartment of Orthopedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Kate KernanDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pa; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Daniel KietzDivision of Rheumatology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Allyson LarkinDivision of Allergy/Immunology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Hey ChongDivision of Allergy/Immunology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Kara CoffeyDivision of Allergy/Immunology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pa. Electronic address: coffeyke2@upmc.edu.

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
University of Pittsburgh Training Program in Antimicrobial ResistanceT32AI138954 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2019 to 2023
$971k
Genetic Variants of Immune Dysregulation and Thrombotic Microangiopathy in Severe Pediatric Sepsis Induced Organ DysfunctionK23GM148827 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kathryn MARY Kernan · 2023 to 2026
$652k
NIAID NIH HHS L30 AI147146NIAID NIH HHS T32 AI138954NICHD NIH HHS K12 HD000850NIGMS NIH HHS K23 GM148827
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Common Variable ImmunodeficiencyMutationNF-kappa B p50 SubunitFemaleHumansInflammationInterleukin-1MalePostoperative ComplicationsRNA Splice SitesInterleukin-1NF-kappa B p50 SubunitNFKB1 protein, humanRNA Splice Sites

Identifiers

PMID38901617
PMCPMC11464186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.