ArticleNeuron2024
Opto-seq reveals input-specific immediate-early gene induction in ventral tegmental area cell types.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures.Neuropsychopharmacology reports · 2026Article
- Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Molecular signatures of resilience to Alzheimer's disease in neocortical layer 4 neurons.Nature communications · 2026Article
- Fentanyl blockade of KThe Journal of physiology · 2026Article
- Role of molecularly defined lateral septum cell types and circuits in social behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Projection-defined ventral tegmental area neurons exhibit fentanyl-induced molecular and functional adaptations that differentially support drug-context associations.bioRxiv : the preprint server for biology · 2025Article
- Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns.NAR genomics and bioinformatics · 2025Article
- Ventral tegmental area GABA neurons integrate positive and negative valence.Nature communications · 2025Article
- Ventral tegmental area GABA neurons integrate positive and negative valence.bioRxiv : the preprint server for biology · 2025Article
- Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns.bioRxiv : the preprint server for biology · 2025Article
- Molecular heterogeneity and development of the ventral tegmental area.Current opinion in behavioral sciences · 2025Article
- How Dopamine Enables Learning from Aversion.Current opinion in behavioral sciences · 2025Article
- Single-Cell RNA-Sequencing of Zebrafish Olfactory Epithelium Identifies Odor-Responsive Candidate Olfactory Receptors.Genes to cells : devoted to molecular & cellular mechanisms · 2025Article
- Monosynaptic ventral tegmental area glutamate projections to the locus coeruleus enhance aversive processing.bioRxiv : the preprint server for biology · 2024Article
- Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta.Addiction neuroscience · 2024Article
- Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation.Cell reports · 2024Article
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Authors and funding
10 authors.
Funding
Abstract
The ventral tegmental area (VTA) is a critical node in circuits governing motivated behavior and is home to diverse populations of neurons that release dopamine, gamma-aminobutyric acid (GABA), glutamate, or combinations of these neurotransmitters. The VTA receives inputs from many brain regions, but a comprehensive understanding of input-specific activation of VTA neuronal subpopulations is lacking. To address this, we combined optogenetic stimulation of select VTA inputs with single-nucleus RNA sequencing (snRNA-seq) and highly multiplexed in situ hybridization to identify distinct neuronal clusters and characterize their spatial distribution and activation patterns. Quantification of immediate-early gene (IEG) expression revealed that different inputs activated select VTA subpopulations, which demonstrated cell-type-specific transcriptional programs. Within dopaminergic subpopulations, IEG induction levels correlated with differential expression of ion channel genes. This new transcriptomics-guided circuit analysis reveals the diversity of VTA activation driven by distinct inputs and provides a resource for future analysis of VTA cell types.
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