Evidence map›Paper›PMID 38901429›Full record

ArticleBiophysical journal2024

Proteins clump: Mechanics and transport during neurodegeneration.

David Gazzo, Tamara L Kinzer-Ursem, Jeremiah J Zartman

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David GazzoDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana; Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana.
Tamara L Kinzer-UrsemWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.
Jeremiah J ZartmanDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana; Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana. Electronic address: jzartman@nd.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This summary of recent contributions in the Biophysical Journal from 2020 to 2023 highlights new mechanistic insights into key biomechanical and biophysical aspects of neurodegeneration. Neurodegeneration encompasses complex diseases characterized by the progressive loss of neuronal function, often linked to protein accumulation and aggregation. Several factors, including mechanical properties and structural composition of brain tissue, formation of proteinaceous condensates within cells, and protein transport between cells, impact the loss of neural function.

Indexed as

Neurodegenerative DiseasesAnimalsBiomechanical PhenomenaHumansMechanical PhenomenaProtein Transport

Identifiers

PMID38901429
PMCPMC11365098

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.