Evidence map›Paper›PMID 38901254›Full record

ArticleJournal of hazardous materials2024

Induction of fibrosis following exposure to bisphenol A and its analogues in 3D human uterine leiomyoma cultures.

Jingli Liu, Linda Yu, Lysandra Castro, Yitang Yan, Pierre Bushel, Erica Scappini, Darlene Dixon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hazardous materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Modeling Uterine Fibroids Using Bioengineered Hydrogels.ACS biomaterials science & engineering · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingli LiuMolecular Pathogenesis Group, Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT), NIEHS, NIH, Research Triangle Park, NC 27709, USA.
Linda YuMolecular Pathogenesis Group, Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT), NIEHS, NIH, Research Triangle Park, NC 27709, USA.
Lysandra CastroMolecular Pathogenesis Group, Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT), NIEHS, NIH, Research Triangle Park, NC 27709, USA.
Yitang YanMolecular Pathogenesis Group, Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT), NIEHS, NIH, Research Triangle Park, NC 27709, USA.
Pierre BushelBlueRock Therapeutics, New York, NY 10016, United States.
Erica ScappiniSignal Transduction Laboratory, DIR, NIEHS, NIH, Research Triangle Park, NC 27709, United States.
Darlene DixonMolecular Pathogenesis Group, Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT), NIEHS, NIH, Research Triangle Park, NC 27709, USA. Electronic address: dixon@niehs.nih.gov.

Funding

Pathobiology Of Uterine Leiomyomas (fibroids)ZIAES021196 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DIXON, DARLENE · 2009 to 2025
$31.7M
PATHOBIOLOGY OF UTERINE LEIOMYOMAS (FIBROIDS)Z01ES021196 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DIXON, DARLENE · 1994 to 2008
$3.9M
Intramural NIH HHS Z01 ES021196Intramural NIH HHS ZIA ES021196
6 · The paper itself

Abstract

Bisphenol A (BPA) and its analogues (BPAF, BPS) are ubiquitous environmental contaminants used as plastic additives in various daily life products, with many concerns on their role as environmental estrogens. Uterine leiomyomas (fibroids) are highly prevalent gynecologic tumors with progressive fibrosis. Fibroids are hormone-responsive and may be the target of environmental estrogens. However, the effects of BPA, BPAF, and BPS exposure on uterine fibrosis are largely unknown. Here, we evaluated fibrosis and the crucial role of TGF-beta signaling in human fibroid tumors, the profibrotic effects of BPA, BPAF or BPS in a human 3D uterine leiomyoma (ht-UtLM) in vitro model, and the long-term outcomes of BPAF exposure in rat uterus. In 3D ht-UtLM spheroids, BPA, BPAF, and BPS all promoted cell proliferation and fibrosis by increasing the production of extracellular matrices. Further mechanistic analysis showed the profibrotic effects were induced by TGF-beta signaling activation mainly through SMAD2/3 pathway and crosstalk with multiple non-SMAD pathways. Furthermore, the profibrotic effects of BPAF were supported by observation of uterine fibrosis in vivo in rats following long-term BPAF exposure. Overall, the 3D ht-UtLM spheroid can be an important model for investigating environment-induced fibrosis in uterine fibroids. BPA and its analogues can induce fibrosis via TGF-beta signaling.

Indexed as

Benzhydryl CompoundsFibrosisLeiomyomaPhenolsTransforming Growth Factor betaUterine NeoplasmsAnimalsBisphenol A CompoundsCell Line, TumorCell ProliferationFemaleHumansRatsRats, Sprague-DawleySignal TransductionUterusBenzhydryl Compoundsbisphenol ABisphenol A CompoundsPhenolsTransforming Growth Factor betaBisphenol ABisphenol AFBisphenol SProfibrotic effectTGF-beta SignalingUterine leiomyomas

Identifiers

PMID38901254
PMCPMC11309888

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.