Evidence map›Paper›PMID 38901111›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2024

Abnormalities of cortical stimulation strength-duration time constant in amyotrophic lateral sclerosis.

Nathan A Pavey, Parvathi Menon, Angel V Peterchev, Matthew C Kiernan, Steve Vucic

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Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Nathan A PaveyBrain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia.
Parvathi MenonBrain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia.
Angel V PeterchevDepartment of Biological Sciences, Dartmouth College, Hanover, NH, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Psychiatry and Behavioural Sciences, Duke University, Durham, NC, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA; Department of Neurosurgery, Duke University, Durham, NC, USA.
Matthew C KiernanNeuroscience Research, Australia.
Steve VucicBrain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia. Electronic address: steve.vucic@sydney.edu.au.

Funding

Biology and Biophysics of the Cortical Response to Transcranial Magnetic StimulationR01NS117405 · NINDS · DUKE UNIVERSITY · PI PETERCHEV, ANGEL V, SOMMER, MARC A · 2020 to 2024
$3.3M
NeuroSimNIBS: Integrated electric field and neuronal response modeling for transcranial electric and magnetic stimulationR01MH128422 · NIMH · DUKE UNIVERSITY · PI Warren M. Grill, Angel V Peterchev · 2022 to 2026
$2.7M
MPS-TMS: Modular Pulse Synthesizer for Transcranial Magnetic Stimulation with Fully Adjustable Pulse Shape and SequenceTBDRF1MH124943 · NIMH · DUKE UNIVERSITY · PI PETERCHEV, ANGEL V · 2020 to 2020
$1.6M
NIMH NIH HHS R01 MH128422NIMH NIH HHS RF1 MH124943NINDS NIH HHS R01 NS117405
6 · The paper itself

Abstract

objectivesStrength-duration time constant (SDTC) may now be determined for cortical motor neurones, with activity mediated by transient Na

methodsCortical SDTC and rheobase were estimated from 17 ALS patients using a controllable pulse parameter transcranial magnetic stimulation (cTMS) device. Resting motor thresholds (RMTs) were determined at pulse widths (PW) of 30, 45, 60, 90 and 120 µs and M-ratio of 0.1, using a figure-of-eight coil applied to the primary motor cortex.

resultsSDTC was significantly reduced in ALS patients (150.58 ± 9.98 µs; controls 205.94 ± 13.7 µs, P < 0.01). The reduced SDTC correlated with a rate of disease progression (Rho = -0.440, P < 0.05), ALS functional rating score (ALSFRS-R) score (Rho = 0.446, P < 0.05), and disease duration (R = 0.428, P < 0.05). The degree of change in SDTC was greater in patients with cognitive abnormalities as manifested by an abnormal total Edinburgh Cognitive ALS Screen score (140.5 ± 28.7 µs, P < 0.001) and ALS-specific subscore (141.7 ± 33.2 µs, P = 0.003).

conclusionsCortical SDTC reduction was associated with a more aggressive ALS phenotype, or with more prominent cognitive impairment. SIGNIFICANCE: An increase in transient Na

Indexed as

Amyotrophic Lateral SclerosisEvoked Potentials, MotorMotor CortexTranscranial Magnetic StimulationAdultAgedFemaleHumansMaleMiddle AgedMotor NeuronsAmyotrophic Lateral SclerosisControllable transcranial magnetic stimulationMotor evoked potentialStrength duration time constant

Identifiers

PMID38901111
PMCPMC11345808

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