Evidence map›Paper›PMID 38900999›Full record

ArticleOrganic letters2024

Expanding the Chemical Space of Electrophilic β-Glycosyl β-Lactams through Photoinduced Diastereoselective Functionalization.

Éverton A Tordato, Renan O Gonçalves, Lucas L Baldassari, Claudio A Jiménez, Diogo S Lüdtke, Márcio W Paixão

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Éverton A TordatoLaboratory for Sustainable Organic Synthesis and Catalysis - Chemistry Department - Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.
Renan O GonçalvesLaboratory for Sustainable Organic Synthesis and Catalysis - Chemistry Department - Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.
Lucas L BaldassariLaboratory for Sustainable Organic Synthesis and Catalysis - Chemistry Department - Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.
Claudio A JiménezDepartment of Organic Chemistry, Faculty of Chemical Sciences, Universidad de Concepción, Concepción 4130000, Chile.ORCID 0000-0002-2622-8308
Diogo S LüdtkeInstitute of Chemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, Rio Grande do Sul 91501-970, Brazil.ORCID 0000-0002-9135-4298
Márcio W PaixãoLaboratory for Sustainable Organic Synthesis and Catalysis - Chemistry Department - Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.ORCID 0000-0002-0421-2831

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we present a photoinduced diastereoselective C-3 functionalization of electrophilic β-glycosyl β-lactams. The developed protocol is simple, mild, and scalable and explores the use of 3-exomethylene β-lactams as reaction partners in a Giese type reaction. The key nucleophilic alkyl radical is generated by a photoinduced electron transfer process in the EDA complex formed by NHPI and Hantzsch esters. The diastereoselective hydrogen atom transfer to the β-lactam radical intermediate enables the synthesis of various

Identifiers

PMID38900999
PMCPMC11232025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.