Evidence map›Paper›PMID 38900773›Full record

ArticlePloS one2024

Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol.

Jai K Das, Zahra Ali Padhani, Muhammad Khan, Mushtaq Mirani, Arjumand Rizvi, Imran Ahmed Chauhadry, Rahima Yasin, Tariq Ismail, Saeed Akhtar, Kehkashan Begum and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06092515 (EZAFFAW - Efficacy of Zinc Fortified Fermented Wheat Flour), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06092515 nacompletednot on this map

EZAFFAW - Efficacy of Zinc Fortified Fermented Wheat Flour: Randomized Controlled Trial

TypeinterventionalSponsorAga Khan UniversityRan2023 to 2024Enrolled1,044ConditionsMalnutrition, Diabetes, Inflammation, ConjunctivitisArmsFermented High Zinc Wheat Flour Flatbread, Unfermented High Zinc Wheat Flour Flatbread, Post-Harvest Fortified Whole Wheat Flour Flatbread, Low Zinc Whole Wheat Flour Flatbread (Control Group)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jai K DasInstitute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.ORCID 0000-0002-2966-7162
Zahra Ali PadhaniInstitute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.
Muhammad KhanInstitute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.
Mushtaq MiraniInstitute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.
Arjumand RizviCentre of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan.
Imran Ahmed ChauhadryCentre of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan.
Rahima YasinInstitute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.
Tariq IsmailInstitute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Saeed AkhtarInstitute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Kehkashan BegumNutrition Research Laboratory, The Aga Khan University, Karachi, Pakistan.ORCID 0000-0002-1933-4313
Junaid IqbalNutrition Research Laboratory, The Aga Khan University, Karachi, Pakistan.
Khadija HumayunDepartment of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan.
Hamna Amir NaseemInstitute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.ORCID 0000-0002-6853-8400
Kauser Abdulla MalikSchool of Life Sciences, Forman Christian College (A Chartered University), Lahore, Pakistan.
Zulfiqar A BhuttaInstitute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundZinc deficiency poses significant health risks, particularly in low-income settings. This study aims to evaluate the impact of agronomically zinc biofortified (fermented and non-fermented) and post-harvest wheat flour flatbread on zinc status and metabolic health in adolescents and adult women in rural Pakistan.

methodsA four-arm triple-blind randomized controlled trial will be conducted in a rural district of Pakistan. Participants (adolescents aged 10-19 and adult women aged 20-40) will be assigned to receive fermented or unfermented high zinc agronomically biofortified wheat flour flatbread, post-harvest zinc-fortified wheat flour flatbread, or low zinc conventional whole wheat flour flatbread. The meal would be served once a day, six days a week for six months. The study aims to enroll 1000 participants and will be analyzed based on the intention-to-treat principle. The trial is registered with number NCT06092515. OUTCOMES: Primary outcomes will include serum zinc concentration and metabolic markers, while secondary outcomes include anthropometric measurements, blood pressure, and dietary intake.

conclusionThis trial will provide valuable insights into the efficacy of agronomically zinc biofortified wheat flour in improving zinc status and metabolic health. Findings may inform public health strategies to combat zinc deficiency in resource-limited settings.

Indexed as

FlourFood, FortifiedTriticumZincAdolescentAdultChildFemaleFermentationHumansMalePakistanRandomized Controlled Trials as TopicYoung AdultZinc

Identifiers

PMID38900773
PMCPMC11189184

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.