Evidence map›Paper›PMID 38900603›Full record

ArticleThe Pediatric infectious disease journal2024

Assessing the Burden of Respiratory Syncytial Virus-related Bronchiolitis in Primary Care and at 15-Day and 6-Month Follow-up Before Prophylaxis in France: A Test-negative Study.

Alexis Rybak, Robert Cohen, Mathieu Bangert, Rolf Kramer, Jean-François Delobbe, Patrice Deberdt, Fabienne Cahn-Sellem, Stéphane Béchet, Corinne Levy

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pediatric infectious disease journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04743609 (Ambulatory Respiratory Tract Infection Survey, Burden of Respiratory Syncitial Virus in the Era of Covid-19), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04743609 narecruitingnot on this map

Ambulatory Respiratory Tract Infection Survey, Burden of Respiratory Syncitial Virus in the Era of Covid-19

TypeinterventionalSponsorAssociation Clinique Thérapeutique Infantile du val de MarneRan2021 to 2026Enrolled1,900ConditionsRSV Infection, Children, Only, Outpatient, OtitisArmsnasopharyngeal samples
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Observational
  7. Economic impact of RSV infections in young children attending primary care: a prospective cohort study in five European countries, 2021 to 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexis RybakFrom the Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France.ORCID 0000-0002-2898-3710
Robert CohenFrom the Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France.
Mathieu BangertSanofi Vaccines, Lyon, France.
Rolf KramerSanofi Vaccines, Lyon, France.
Jean-François DelobbeAssociation Française de Pédiatrie Ambulatoire, Paris.
Patrice DeberdtAssociation Française de Pédiatrie Ambulatoire, Paris.
Fabienne Cahn-SellemAssociation Française de Pédiatrie Ambulatoire, Paris.
Stéphane BéchetFrom the Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France.
Corinne LevyFrom the Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France.

Funding

Sanofi Paster
6 · The paper itself

Abstract

objectiveTo assess the burden of respiratory syncytial virus (RSV)-related bronchiolitis in primary care and at 15 days and 6 months after a primary care visit. STUDY

designIn this test-negative study, children <2 years old with a first episode of bronchiolitis were prospectively enrolled by 45 ambulatory pediatricians in France from February 2021 to April 2023. RSV was assessed with a rapid antigen detection test. The burden of the disease was assessed with a questionnaire, including quality of life (PedsQL 1.0 Infant Scales), at 15-day and 6-month follow-up. Children with a positive RSV test result (RSV+) were compared to those with a negative test result (RSV-).

resultsAmong the 1591 children enrolled, 750 (47.1%) were RSV+. At 15 days follow-up (data availability: 69%), as compared with RSV- children, RSV+ children more frequently had fever (20.5% vs. 13.7%, P = 0.004) and decreased food intake (27.0% vs. 17.4%, P < 0.001) during the last 3 days. They had higher rates of hospitalization (11.8% vs. 5.8%, P < 0.001), childcare absenteeism (83.5% vs. 66.1%, P < 0.001) and parents who had to stop working to care for them (59.1% vs. 41.0%, P < 0.001) as well as lower quality of life (median PedsQL score 76.2 vs. 78.4, P = 0.03). At 6 months (data availability: 48.5%), the 2 groups did not differ in proportion of medical attendance, hospitalization, antibiotic treatment or quality of life.

conclusionRSV+ children experienced much more severe disease and follow-up family and societal burden than RSV- children. These data may be used as baseline data as RSV prophylaxis is about to be implemented.

Indexed as

Primary Health CareQuality of LifeRespiratory Syncytial Virus InfectionsAntiviral AgentsBronchiolitisCost of IllnessFemaleFollow-Up StudiesFranceHumansInfantInfant, NewbornMaleProspective StudiesRespiratory Syncytial Virus, HumanSurveys and QuestionnairesAntiviral Agents

Identifiers

PMID38900603
PMCPMC11185926

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.