ArticleeLife2024
Spatial and temporal pattern of structure-function coupling of human brain connectome with development.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Excessive Censoring Degrades Individual-Specific Cortical Parcellations and Personalized TMS Targets.bioRxiv : the preprint server for biology · 2026Article
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- Primary cilia and neural computation.Journal of biomedical science · 2026Review
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- White matter structure-function coupling in neonatal brain and its association with Autism-related traits in early childhood.Translational psychiatry · 2026Article
- Tract-explainable and underexplained synchrony play complementary roles in the functional organization of the brain.bioRxiv : the preprint server for biology · 2026Article
- Decoupling of neurophysiological activity from structure mirrors global microarchitectural and neuromodulatory trends.Communications biology · 2026Article
- Brain functional-structural gradient coupling reflects development, behavior and genetic influences.Nature communications · 2026Article
- Dual-axis myelination covariance drives the functional connectivity emergence during infancy.Nature communications · 2026Article
- Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity.Function (Oxford, England) · 2026Review
- Lifestyle and Transcriptional Signatures Associated with Ethnicity/Race-Related Variations in the Functional Connectome.Research (Washington, D.C.) · 2026Article
- 40 Years of diffusion MRI in the brain: From history to emerging frontiers.Imaging neuroscience (Cambridge, Mass.) · 2026Review
- Multimodal brain network disruption and structural-functional decoupling in overt hypothyroidism.Frontiers in endocrinology · 2026Article
- Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Cellular and molecular associations with intrinsic brain organization.Nature communications · 2025Article
- Cellular and molecular associations with intrinsic brain organization.bioRxiv : the preprint server for biology · 2025Article
- Cognitive Compensation Depends on Frontoparietal Network Structure-Function Coupling in Patients With White Matter Hyperintensity.Brain and behavior · 2025Article
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6 authors.
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Abstract
Brain structural circuitry shapes a richly patterned functional synchronization, supporting for complex cognitive and behavioural abilities. However, how coupling of structural connectome (SC) and functional connectome (FC) develops and its relationships with cognitive functions and transcriptomic architecture remain unclear. We used multimodal magnetic resonance imaging data from 439 participants aged 5.7-21.9 years to predict functional connectivity by incorporating intracortical and extracortical structural connectivity, characterizing SC-FC coupling. Our findings revealed that SC-FC coupling was strongest in the visual and somatomotor networks, consistent with evolutionary expansion, myelin content, and functional principal gradient. As development progressed, SC-FC coupling exhibited heterogeneous alterations dominated by an increase in cortical regions, broadly distributed across the somatomotor, frontoparietal, dorsal attention, and default mode networks. Moreover, we discovered that SC-FC coupling significantly predicted individual variability in general intelligence, mainly influencing frontoparietal and default mode networks. Finally, our results demonstrated that the heterogeneous development of SC-FC coupling is positively associated with genes in oligodendrocyte-related pathways and negatively associated with astrocyte-related genes. This study offers insight into the maturational principles of SC-FC coupling in typical development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.