Evidence map›Paper›PMID 38900507›Full record

ArticleeLife2024

Metabolic regulation of misfolded protein import into mitochondria.

Yuhao Wang, Linhao Ruan, Jin Zhu, Xi Zhang, Alexander Chih-Chieh Chang, Alexis Tomaszewski, Rong Li

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. In and out of the mitochondrial intermembrane space.Protein science : a publication of the Protein Society · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Cardiac diastolic dysfunction by cigarette smoking is associated with mitochondrial integrity in the heart.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  13. Article
  14. GPI-anchored Gas1 protein regulates cytosolic proteostasis in yeast.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yuhao Wang *Center for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-2491-6916
Linhao Ruan *Center for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-6231-2566
Jin ZhuMechanobiology Institute and Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Xi ZhangCenter for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Alexander Chih-Chieh ChangCenter for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Alexis TomaszewskiCenter for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Rong LiCenter for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-0540-6566

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Cellular dynamics in division, motility and evolutionary adaptationR35GM118172 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI LI, RONG · 2016 to 2019
$2.8M
American Heart Association Predoctoral Fellowship AHA 17PRE33670517Johns Hopkins University Isaac Morris Hay and Lucille Elizabeth Hay Graduate FellowshipNIGMS NIH HHS R35 GM118172NIGMS NIH HHS T32 GM007445NIH HHS BCMB graduate program at Johns Hopkins School of Medicine T32 GM007445NIH HHS Grant R35 GM118172
6 · The paper itself

Abstract

Mitochondria are the cellular energy hub and central target of metabolic regulation. Mitochondria also facilitate proteostasis through pathways such as the 'mitochondria as guardian in cytosol' (MAGIC) whereby cytosolic misfolded proteins (MPs) are imported into and degraded inside mitochondria. In this study, a genome-wide screen in

Indexed as

MitochondriaProtein FoldingProtein TransportSaccharomyces cerevisiaeGlucoseHumansProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsGlucoseProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsSNF1-related protein kinasesAMPKcell biologyhumanMAGICmetabolismmisfolded proteinmitochondriaprotein importproteostasisS. cerevisiae

Identifiers

PMID38900507
PMCPMC11189628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.