Evidence map›Paper›PMID 38900360›Full record

ArticleJournal of materials science. Materials in medicine2024

In vitro cytocompatibility of triclosan coated Polyglactin910 sutures.

Hongrui Ji, Zhiruo Zhang, Chao Wang, Xuewen Li, Guiling Zhang, Danqing Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Frontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongrui Ji *School of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin, 150040, Heilongjiang, China. jihongrui@hrbust.edu.cn.
Zhiruo Zhang *School of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin, 150040, Heilongjiang, China.
Chao WangSchool of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin, 150040, Heilongjiang, China.
Xuewen LiSchool of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin, 150040, Heilongjiang, China.
Guiling ZhangSchool of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin, 150040, Heilongjiang, China. 2583678873@qq.com.
Danqing LiuSchool of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin, 150040, Heilongjiang, China. 450313845@qq.com.

Funding

Heilongjiang University Student Innovation Experiment Project S202210214035
6 · The paper itself

Abstract

Bioabsorbable sutures can improve the medical functions of existing non-absorbable sutures, and may produce new medical effects, and are expected to become a new generation of medical degradable materials. In this study, the cytocompatibility of triclosan coated polyglactin910 sutures (CTS-PLGA910) was analyzed and different concentrations of sutures were prepared. The effects of sutures on the cytotoxicity and cell proliferation of HUVEC were studied by CCK-8 assay. The hemolysis, total antioxidant capacity (T-AOC) activity and nitric oxide (NO) content were investigated to improve the blood compatibility of sutures. The results showed that the hemolysis rate of CTS-PLGA910 was less than 5%. After treatment on HUVEC cells for 48 and 72 h, there was no significant change in NO content in CTS-PLGA910 groups compared with the control group, while T-AOC activity and antioxidant capacity were significantly increased in medium and high dose groups. In summary, the blood compatibility and cell compatibility were significantly improved, which provided a basis for the clinical application of sutures in the future.

Indexed as

Cell ProliferationCoated Materials, BiocompatibleHuman Umbilical Vein Endothelial CellsMaterials TestingPolyglactin 910SuturesTriclosanAntioxidantsBiocompatible MaterialsCell SurvivalHemolysisHumansNitric OxideAntioxidantsBiocompatible MaterialsCoated Materials, BiocompatibleNitric OxidePolyglactin 910TriclosanCell proliferation testCompatibilityHemolysis rate testHuman umbilical vein endothelial cellsTriclosan coated polyglactin910 sutures

Identifiers

PMID38900360
PMCPMC11189944

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.