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ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024

Undiagnosed vertebral fragility fractures in patients with distal radius fragility fractures: an opportunity for prevention of morbimortality in osteoporotic patients in developing countries.

Muhammad Muzzammil, Sikandar Bhura, Adnan Shabbir Hussain, Shehroz Bashir, Sana Dur Muhammad, Mayank Kumar, Abdul Qadir, Syed Jahanzeb, Syed Ghulam Mujtaba Shah

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Muhammad MuzzammilDepartment of Orthopedics, Sindh Gov. Services Hospital, Karachi, Pakistan. muzzammil_sangani@hotmail.com.ORCID http://orcid.org/0000-0003-4713-3081
Sikandar BhuraKutiyana Memon Hospital, Karachi City, Sindh, Pakistan.
Adnan Shabbir HussainCardiff University Hospital, Cardiff, Wales.
Shehroz BashirEmergency Department, Hamad Medical Corporation, Doha, Qatar.
Sana Dur MuhammadJinnah Postgraduate Medical Center, Karachi, Pakistan.
Mayank KumarT&O, CUH NHS Trust, Cambridge, England.
Abdul QadirDepartment of Orthopedics, Dr Ruth K M Pfau Civil Hospital, Karachi, Pakistan.
Syed JahanzebDepartment of Orthopedics, Dr Ruth K M Pfau Civil Hospital, Karachi, Pakistan.
Syed Ghulam Mujtaba ShahDepartment of Orthopedics, Sindh Gov. Services Hospital, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our study investigates vertebral fractures in individuals with distal radius fractures. Among 512 patients, 41.21% had vertebral fractures, predominantly in the lumbar spine. These findings highlight the importance of screening for vertebral fractures in this population, informing early intervention strategies to mitigate risks associated with osteoporosis. PURPOSE: This study's main goal was to look into the frequency, location, kind, and severity of asymptomatic vertebral fragility fractures (VFF) in people who had fractures of the fragility of the distal radius. Although VFF is frequently misdiagnosed, it is linked to higher mortality, morbidity, and hip fracture risk. The study also attempted to investigate the relationship between VFF and certain demographic and lifestyle factors, as well as FRAX data, in this patient population.

methodsBetween January, 2021, and January, 2022, individuals with low-energy distal radial fractures who presented to the emergency room of tertiary care hospital of Karachi, Pakistan, were the subject of a cross-sectional study and were 45 years of age or older except those who fitted the exclusion criteria (n = 208). The thoracic and/or lumbar spine was imaged using radiology, and information on demographics, way of life, and FRAX (Fracture Risk Assessment Tool) was gathered. Using the Genant semiquantitative approach, an impartial and blinded orthopaedist identified VF in the images and determined their severity. SPSS version 20 was used to analyse the data.

resultsTwo hundred eleven (41.21%) of them were found to have radiographic VFF and only 12 (2.34%) of the 512 patients who were tested were getting osteoporotic therapy. The thoracic spine (32.7%), followed by the lumbar spine (43.12%), was the area most frequently afflicted. In 24.17% of the patients, multiple fractures of the thoracolumbar spine were found. The wedge form (54.5%), followed by biconcave (30.81%) and crush (14.7%), was the most prevalent VFF type. The majority of detected VFF were rated as having a 25-40% height loss (64.9%) then severe (> 40%) fractures (35.1%), according to the Genant grading method. Notably, there were no variations in smoking, drinking, BMI, or FRAX score between patients with and without VFF that were statistically significant.

conclusionBased on our study's findings, it is clear that osteoporotic vertebral fragility fractures occur in almost half of individuals with distal radius fractures. The lumbar spine is notably the most affected region, predominantly with wedge fractures. Given the high prevalence of asymptomatic vertebral fragility fractures (VFF), proactive measures are necessary to mitigate associated risks. Prioritising comprehensive fall risk assessments for these patients and interventions to enhance bone mineral density and strength are crucial. Early identification of asymptomatic VFF enables timely intervention, optimising patient care and minimising the risk of complications in this vulnerable population.

Indexed as

Lumbar VertebraeOsteoporotic FracturesRadius FracturesSpinal FracturesAgedAged, 80 and overCross-Sectional StudiesDeveloping CountriesFemaleHumansMaleMiddle AgedPakistanRisk AssessmentThoracic VertebraeDeveloping countryDistal radius fractureOsteoporosisVertebral fragility fracture

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.