Evidence map›Paper›PMID 38900055›Full record

ArticleJournal of studies on alcohol and drugs2025

The Longitudinal Association of Cumulative Depression With Cannabis Use Disorder Among Young Adults.

Isaac C Rhew, Sabrina Oesterle, Margaret R Kuklinski, Katarina Guttmannova, Jennifer M Cadigan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of studies on alcohol and drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isaac C RhewCenter for the Study of Health and Risk Behaviors, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Sabrina OesterleSouthwest Interdisciplinary Research Center, School of Social Work, Arizona State University, Phoenix, Arizona.
Margaret R KuklinskiSocial Development Research Group, School of Social Work, University of Washington, Seattle, Washington.
Katarina GuttmannovaCenter for the Study of Health and Risk Behaviors, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Jennifer M CadiganCenter for the Study of Health and Risk Behaviors, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.

Funding

The Community Youth Development Study: A Test of Communities That CareR01DA015183 · NIDA · UNIVERSITY OF WASHINGTON · PI HAWKINS, J DAVID, OESTERLE, SABRINA · 2003 to 2016
$34.0M
The interplay of social, normative, and legal marijuana environments and marijuana and ATOD use from late childhood to young adulthoodR01DA044522 · NIDA · UNIVERSITY OF WASHINGTON · PI KUKLINSKI, MARGARET, OESTERLE, SABRINA · 2018 to 2022
$4.3M
The interplay of social, normative, and legal marijuana environments and marijuana and ATOD use from late childhood to young adulthoodR56DA044522 · NIDA · UNIVERSITY OF WASHINGTON · PI OESTERLE, SABRINA · 2017 to 2017
$350k
NIDA NIH HHS R01 DA015183NIDA NIH HHS R01 DA044522NIDA NIH HHS R56 DA044522
6 · The paper itself

Abstract

objectiveThis study examined whether the cumulative experience of elevated depressive symptoms from ages 19 to 23 was associated with cannabis use disorder (CUD) at age 26 and whether the association varied by perceived ease of access to cannabis and perceived risk for harms from cannabis use.

methodData were from 4,407 young adults participating in the Community Youth Development Study. Cumulative experience of elevated depressive symptoms was calculated by summing the number of times a participant scored ≥10 on the 9-item Patient Health Questionnaire across three biennial survey waves (ages 19 to 23). To assess CUD, the Diagnostic Interview Schedule was used. Participants also self-reported their ease of access to cannabis and the perceived harm of regular cannabis use at the age 19, 21, and 23 waves. Marginal structural modeling was used to account for multiple time-varying and time-fixed covariates using inverse probability weights.

resultsIn the final weighted models, a greater number of time points (i.e., study waves) showing elevated depressive symptoms was associated with an increased likelihood of CUD at age 26 (prevalence ratio = 1.46, 95% CI [1.20, 1.77]). There was no strong evidence for moderation of this association by perceived ease of access or perceived risk for harms because of regular cannabis use.

conclusionsPersistent experience of elevated depressive symptoms may place young adults at risk for CUD. Strategies to reduce the burden of depressive symptoms among young adults may lead to downstream effects such as reducing the prevalence of cannabis-related problems.

Indexed as

DepressionMarijuana AbuseAdultFemaleHumansLongitudinal StudiesMalePrevalenceYoung Adult

Identifiers

PMID38900055
PMCPMC11822757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.