Evidence map›Paper›PMID 38899927›Full record

ArticleAntimicrobial agents and chemotherapy2024

Characterization of antimalarial activity of artemisinin-based hybrid drugs.

Helenita Costa Quadros, Lars Herrmann, Jeanne Manaranche, Lucie Paloque, Mariana C Borges-Silva, Godwin Akpeko Dziwornu, Sarah D'Alessandro, Kelly Chibale, Nicoletta Basilico, Françoise Benoit-Vical and 2 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Helenita Costa QuadrosInstituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil.ORCID 0000-0002-7191-4809
Lars HerrmannOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-Universität of Erlangen-Nürnberg, Erlangen, Germany.
Jeanne ManarancheLCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.
Lucie PaloqueLCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-0359-3959
Mariana C Borges-SilvaInstituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil.ORCID 0000-0001-5581-7542
Godwin Akpeko DziwornuDrug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, South Africa.ORCID 0000-0003-1668-8818
Sarah D'AlessandroDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0001-9241-9762
Kelly ChibaleDrug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, South Africa.ORCID 0000-0002-4541-646X
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Chirurgiche e Odontoiatriche, Universitá degli Studi di Milano, Milan, Italy.ORCID 0000-0001-9030-1066
Françoise Benoit-VicalLCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0002-9468-4823
Svetlana B TsogoevaOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-Universität of Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0003-4845-0951
Diogo Rodrigo M MoreiraInstituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil.ORCID 0000-0003-3323-4404

Funding

Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst (Bavarian State Ministry of Education, Science and the Arts) EQU202103012596Centre National de la Recherche Scientifique (CNRS)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 305732/2019-6Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 440227/2022-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 001Deutsche Forschungsgemeinschaft (DFG) TS87/28-1Fondation pour la Recherche Médicale (FRM)Fundação Oswaldo Cruz (FIOCRUZ) IGM-002-FIO-20-2-25Institut National de la Santé et de la Recherche Médicale (Inserm)Ministero degli Affari Esteri e della Cooperazione Internazionale (MAECI) 00949-2018
6 · The paper itself

Abstract

In response to the spread of artemisinin (ART) resistance, ART-based hybrid drugs were developed, and their activity profile was characterized against drug-sensitive and drug-resistant

Indexed as

AntimalarialsArtemisininsPlasmodium falciparumAnimalsDrug ResistanceHumansMicrosomes, LiverParasitic Sensitivity TestsPeroxidesAntimalarialsartemisininArtemisininsartenimolPeroxidesartemisinindelayed clearance phenotypeheme detoxificationheme redox homeostasishybrid drugsPlasmodium falciparumreductive bioactivationresistance

Identifiers

PMID38899927
PMCPMC11232401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.