Evidence map›Paper›PMID 38899895›Full record

ArticleJournal of virology2024

Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model.

Christiane Stahl-Hennig, Antonia Sophia Peter, Arne Cordsmeier, Nicole Stolte-Leeb, Ramona Vestweber, Eileen Socher, Samuel Alberto Merida, Ulrike Sauermann, Martina Bleyer, Kirsten Fraedrich and 5 more

Abstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christiane Stahl-Hennig *Unit of Infection Models, German Primate Center, Göttingen, Germany.
Antonia Sophia Peter *Institute of Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-9667-2247
Arne CordsmeierInstitute of Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Nicole Stolte-LeebUnit of Infection Models, German Primate Center, Göttingen, Germany.
Ramona VestweberUnit of Infection Models, German Primate Center, Göttingen, Germany.
Eileen SocherInstitute of Anatomy, Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Samuel Alberto MeridaUnit of Infection Models, German Primate Center, Göttingen, Germany.
Ulrike SauermannUnit of Infection Models, German Primate Center, Göttingen, Germany.
Martina BleyerUnit of Infection Models, German Primate Center, Göttingen, Germany.
Kirsten FraedrichInstitute of Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Thomas GrunwaldDepartment of Vaccines and Infection Models, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
Thomas H WinklerDivision of Genetics, Department Biology, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Armin EnsserInstitute of Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-8873-3863
Hans-Martin JäckDivision of Molecular Immunology, Internal Medicine III, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Klaus ÜberlaInstitute of Clinical and Molecular Virology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-7822-3835

Funding

Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst (Bavarian State Ministry of Education, Science and the Arts) CoVaKo 2021, FOR-COVID-TP1Bundesministerium für Bildung und Forschung (BMBF) 01KI2043Bundesministerium für Bildung und Forschung (BMBF) NaFoUniMedCovid19Bundesministerium für Bildung und Forschung (BMBF) SenseCoV201KI20172ADeutsche Forschungsgemeinschaft (DFG) Fokus COVID-19 EN 423/7-1
6 · The paper itself

Abstract

The potency of antibody neutralization in cell culture has been used as the key criterion for selection of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for clinical development. As other aspects may also influence the degree of protection

Indexed as

Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19Disease Models, AnimalMacaca mulattaSARS-CoV-2Spike Glycoprotein, CoronavirusViral LoadAnimalsEpitopesHumansMutationNeutralization TestsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antibody therapybarrier to resistanceneutralizing monoclonal antibodiesnonhuman primate modelSARS-CoV-2

Identifiers

PMID38899895
PMCPMC11265388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.