Evidence map›Paper›PMID 38899886›Full record

ArticleApplied and environmental microbiology2024

Sub-genomic RNAi-assisted strain evolution of filamentous fungi for enhanced protein production.

Xianhua Sun, Fei Gao, Chao Fan, Shuyan Yang, Tong Zhao, Tao Tu, Huiying Luo, Bin Yao, Huoqing Huang, Xiaoyun Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xianhua Sun *State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID 0000-0001-8058-9094
Fei Gao *State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Chao FanKey Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
Shuyan YangState Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Tong ZhaoInstitute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Tao TuState Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID 0000-0002-1661-0386
Huiying LuoState Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID 0000-0002-4596-2639
Bin YaoState Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Huoqing HuangState Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID 0000-0003-3197-6631
Xiaoyun SuState Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID 0000-0003-0547-9252

Funding

CAAS | Agricultural Science and Technology Innovation Program (ASTIP) CAAS-ZDRW202305China Agricultural Research System (CARS) of MOF and MARA CARS-41China Postdoctoral Science Foundation (China Postdoctoral Foundation Project) BX20220347, 2022M723448MOST | National Key Research and Development Program of China (NKPs) 2021YFC2100204MOST | National Natural Science Foundation of China (NSFC) 32302785
6 · The paper itself

Abstract

Genetic engineering at the genomic scale provides a rapid means to evolve microbes for desirable traits. However, in many filamentous fungi, such trials are daunted by low transformation efficiency. Differentially expressed genes under certain conditions may contain important regulatory factors. Accordingly, although manipulating these subsets of genes only can largely reduce the time and labor, engineering at such a sub-genomic level may also be able to improve the microbial performance. Herein, first using the industrially important cellulase-producing filamentous fungus

Indexed as

CellulaseHypocrealesRNA InterferenceFungal ProteinsGene Expression Regulation, FungalGenetic EngineeringCellulaseFungal Proteinsgenome engineeringHumicola insolensRNA interferencesuppression subtractive hybridizationTrichoderma reesei

Identifiers

PMID38899886
PMCPMC11267940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.