Evidence map›Paper›PMID 38899877›Full record

ReviewClinical microbiology reviews2024

HIV-associated cancers and lymphoproliferative disorders caused by Kaposi sarcoma herpesvirus and Epstein-Barr virus.

Kathryn A Lurain, Ramya Ramaswami, Laurie T Krug, Denise Whitby, Joseph M Ziegelbauer, Hao-Wei Wang, Robert Yarchoan

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathryn A Lurain *The HIV and AIDS Malignancy Branch, Center for Cancer Research, Bethesda, Maryland, USA.
Ramya Ramaswami *The HIV and AIDS Malignancy Branch, Center for Cancer Research, Bethesda, Maryland, USA.
Laurie T Krug *The HIV and AIDS Malignancy Branch, Center for Cancer Research, Bethesda, Maryland, USA.ORCID 0000-0002-9648-522X
Denise WhitbyViral Oncology Section, AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Joseph M ZiegelbauerThe HIV and AIDS Malignancy Branch, Center for Cancer Research, Bethesda, Maryland, USA.ORCID 0000-0001-6464-6941
Hao-Wei WangLaboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.
Robert YarchoanThe HIV and AIDS Malignancy Branch, Center for Cancer Research, Bethesda, Maryland, USA.ORCID 0000-0002-3057-1395

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Flow Cytometric Analysis of Benign and Malignant TumorsZICSC009372 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI WANG, HAO-WEI · 2009 to 2025
$29.6M
Clinical Trials of Patients with AIDS-Related MalignanciesZIABC010888 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YARCHOAN, ROBERT · 2009 to 2025
$20.6M
Study of Tumor Pathogenesis and Development of Therapies for AIDS MalignanciesZIABC010885 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YARCHOAN, ROBERT · 2009 to 2025
$15.7M
Flow Cytometric Evaluation of BiomarkersZICBC011104 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, HAO-WEI · 2009 to 2025
$8.6M
Investigation of viral and host determinants of gammaherpesvirus pathogenesisZIABC011953 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KRUG, LAURIE TATE · 2020 to 2025
$8.1M
FLow Cytometric Detection of Malignant Cells in Body FluidsZICBC011093 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, HAO-WEI · 2009 to 2025
$4.5M
Virus host interactions in clinical samplesZIABC012047 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ZIEGELBAUER, JOSEPH · 2021 to 2025
$4.3M
Targeted therapies for Kaposi sarcoma and KSHV-multicentric Castleman diseaseZIABC011954 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RAMASWAMI, RAMYA · 2020 to 2025
$3.8M
Novel interventions for gammaherpesvirus infection and AIDS-Related MalignanciesZIABC012014 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KRUG, LAURIE TATE · 2020 to 2025
$2.7M
Frederick National Laboratory for Cancer Research (FNLCR) HHSN261201500003I, 75N91019D00024HHS | National Institutes of Health (NIH) ZIA BC010888-16HHS | National Institutes of Health (NIH) ZIA BC011093Intramural NIH HHS ZIA BC010888Intramural NIH HHS ZIA BC011954Intramural NIH HHS ZIA BC012014Intramural NIH HHS ZIA BC012047Intramural NIH HHS ZIC BC011093NCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003I
6 · The paper itself

Abstract

SUMMARYWithin weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin tumor in the USA. It soon became apparent that AIDS was also associated with an increased incidence of high-grade lymphomas caused by Epstein-Barr virus (EBV). The association of AIDS with KS remained a mystery for more than a decade until Kaposi sarcoma-associated herpesvirus (KSHV) was discovered and found to be the cause of KS. KSHV was subsequently found to cause several other diseases associated with AIDS and human immunodeficiency virus (HIV) infection. People living with HIV/AIDS continue to have an increased incidence of certain cancers, and many of these cancers are caused by EBV and/or KSHV. In this review, we discuss the epidemiology, virology, pathogenesis, clinical manifestations, and treatment of cancers caused by EBV and KSHV in persons living with HIV.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanHerpesvirus 8, HumanHIV InfectionsLymphoproliferative DisordersHumansNeoplasmsSarcoma, KaposiAIDSCastlemanEBVgammaherpesvirusHIVKaposiKSHVlymphoma

Identifiers

PMID38899877
PMCPMC11391709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.