Evidence map›Paper›PMID 38899834›Full record

ArticleIntegrative cancer therapies

The Tanshinones (Tan) Extract From

Qin Xu, Shujie Dong, Qiuyi Gong, Qun Dai, Rubin Cheng, Yuqing Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qin XuThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0000-0002-1558-0023
Shujie DongZhejiang Chinese Medical University, Hangzhou, China.
Qiuyi GongZhejiang Chinese Medical University, Hangzhou, China.
Qun DaiThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Rubin ChengZhejiang Chinese Medical University, Hangzhou, China.
Yuqing GeThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveIn this study, we aimed to investigate the therapeutic potential of Tan in pancreatic cancer and elucidate the underlying mechanisms. MATERIALS AND

methodsThe viabilities of PANC-1 and Bxpc-3 cells were determined by MTT assay, after treatment with various concentrations of Tan. The apoptotic cells were quantified by annexin V-FITC/PI staining and DAPI staining assays. The expression of relative proteins was used western blotting. Tumor growth was assessed by subcutaneously inoculating cells into C57BL/6 mice.

resultsOur experiments discovered that Tan effectively suppressed pancreatic cancer cell proliferation and promoted apoptosis. Mechanistically, we propose that Tan enhances intracellular ROS levels by activating the AKT/FOXO3/SOD2 signaling pathway, ultimately leading to apoptosis in pancreatic cancer cells. In vivo assay showed the antitumor effect of Tan.

conclusionTan, a natural compound from

Indexed as

AbietanesApoptosisForkhead Box Protein O3Pancreatic NeoplasmsProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSalvia miltiorrhizaSignal TransductionAnimalsCell Line, TumorCell ProliferationHumansMiceMice, Inbred C57BLPlant ExtractsAbietanesForkhead Box Protein O3FOXO3 protein, humanPlant ExtractsProto-Oncogene Proteins c-aktReactive Oxygen SpeciestanshinoneAKT/FoxO3/SOD2apoptosispancreatic cancerROSSalvia miltiorrhizaTanhinones

Identifiers

PMID38899834
PMCPMC11191618

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.