Evidence map›Paper›PMID 38899573›Full record

ArticleVirulence2024

Screening optimal DC-targeting peptide to enhance the immune efficacy of recombinant

Tian Xia, Xiao Lu, Deming Kong, Tiantian Guo, Yueyi Gao, Lingxiang Xin, Yanping Jiang, Xiaona Wang, Zhifu Shan, Jiaxuan Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tian XiaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Xiao LuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Deming KongCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Tiantian GuoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Yueyi GaoDivision of Viral Biologic Testing(I), China Institute of Veterinary Drug Control, Beijing, China.
Lingxiang XinDivision of Viral Biologic Testing(I), China Institute of Veterinary Drug Control, Beijing, China.
Yanping JiangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Xiaona WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Zhifu ShanCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Jiaxuan LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Han ZhouCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Wen CuiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Xinyuan QiaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Lijie TangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Yijing LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Li WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, China.ORCID 0000-0002-8682-0696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) present an ideal target for delivering immunogenic cargo due to their potent antigen-presenting capabilities. This targeting approach holds promise in vaccine development by enhancing the efficiency of antigen recognition and capture by DCs. To identify a high-affinity targeting peptide binding to rabbit DCs, rabbit monocyte-derived DCs (raMoDCs) were isolated and cultured, and a novel peptide, HS (HSLRHDYGYPGH), was identified using a phage-displayed peptide library. Alongside HS, two other DC-targeting peptides, KC1 and MY, previously validated in our laboratory, were employed to construct recombinant

Indexed as

Dendritic CellsHemorrhagic Disease Virus, RabbitLimosilactobacillus reuteriPeptidesAnimalsCaliciviridae InfectionsCapsid ProteinsLactobacillusRabbitsReoviridae InfectionsViral VaccinesCapsid ProteinsPeptidesViral Vaccinesfusion expressionRabbit dendritic cellsrecombinant LactobacillusRHDV vaccinestargeting

Identifiers

PMID38899573
PMCPMC11195490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.