Evidence map›Paper›PMID 38899557›Full record

SynthesisMovement disorders clinical practice2024

A Pragmatic Review on Spinal Cord Stimulation Therapy for Parkinson's Disease Gait Related Disorders: Gaps and Controversies.

Victor S Hvingelby, Rafael B Carra, Miriam H Terkelsen, Clement Hamani, Tamine Capato, Zuzana Košutzká, Joachim K Krauss, Elena Moro, Nicola Pavese, Rubens G Cury

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Transcutaneous Spinal Magnetic Stimulation Affects Subthalamic Activity in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victor S HvingelbyDepartment of Clinical Medicine - Nuclear Medicine and PET Center, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-4915-7899
Rafael B CarraDepartment of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Miriam H TerkelsenDepartment of Clinical Medicine - Nuclear Medicine and PET Center, Aarhus University, Aarhus, Denmark.
Clement HamaniDivision of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Tamine CapatoDepartment of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Zuzana KošutzkáSecond Department of Neurology, Comenius University Bratislava, Bratislava, Slovakia.ORCID https://orcid.org/0000-0001-6390-0872
Joachim K KraussDepartment of Neurosurgery, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-0675-9064
Elena MoroGrenoble Alpes University, Division of Neurology, CHU of Grenoble, Grenoble Institute of Neurosciences, Grenoble, France.ORCID https://orcid.org/0000-0002-7968-5908
Nicola PaveseClinical Ageing Research Unit Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-6801-6194
Rubens G CuryHospital Israelita Albert Einstein, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's Disease (PD) is a progressive neurological disorder that results in potentially debilitating mobility deficits. Recently, spinal cord stimulation (SCS) has been proposed as a novel therapy for PD gait disorders. The highest levels of evidence remain limited for SCS.

objectivesIn this systematic review and narrative synthesis, the literature was searched using combinations of key phrases indicating spinal cord stimulation and PD.

methodsWe included pre-clinical studies and all published clinical trials, case reports, conference abstracts as well as protocols for ongoing clinical trials. Additionally, we included trials of SCS applied to atypical parkinsonism.

resultsA total of 45 human studies and trials met the inclusion criteria. Based on the narrative synthesis, a number of knowledge gaps and future avenues of potential research were identified. This review demonstrated that evidence for SCS is currently not sufficient to recommend it as an evidence-based therapy for PD related gait disorders. There remain challenges and significant barriers to widespread implementation, including issues regarding patient selection, effective outcome selection, stimulation location and mode, and in programming parameter optimization. Results of early randomized controlled trials are currently pending. SCS is prone to placebo, lessebo and nocebo as well as blinding effects which may impact interpretation of outcomes, particularly when studies are underpowered.

conclusionTherapies such as SCS may build on current evidence and be shown to improve specific gait features in PD. Early negative trials should be interpreted with caution, as more evidence will be required to develop effective methodologies in order to drive clinical outcomes.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseSpinal Cord StimulationHumansfallsfreezing of gaitgait disorderneuromodulationParkinson's diseasespinal cord stimulation

Identifiers

PMID38899557
PMCPMC11329578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.