Evidence map›Paper›PMID 38899555›Full record

ArticleDiabetes, obesity & metabolism2024

Interactions between age, sex and visceral adipose tissue on brain ageing.

Chris Moran, Jarin Herson, Stephanie Than, Taya Collyer, Richard Beare, Sarah Syed, Velandai Srikanth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, obesity & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Relationship between cardiac index and brain volume in the UK Biobank.Cerebral circulation - cognition and behavior · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chris MoranPeninsula Clinical School, Central Clinical School, Monash University, Frankston, Australia.ORCID 0000-0003-1872-3314
Jarin HersonDepartment of Geriatric Medicine, Peninsula Health, Mornington, Australia.
Stephanie ThanPeninsula Clinical School, Central Clinical School, Monash University, Frankston, Australia.
Taya CollyerPeninsula Clinical School, Central Clinical School, Monash University, Frankston, Australia.
Richard BearePeninsula Clinical School, Central Clinical School, Monash University, Frankston, Australia.
Sarah SyedDepartment of Home, Acute and Community, Alfred Health, Caulfield, Australia.
Velandai SrikanthPeninsula Clinical School, Central Clinical School, Monash University, Frankston, Australia.ORCID 0000-0002-8442-8981

Funding

Identifying lifelong factors that impact brain health and outcomes in type 1 diabetes: The Cognition and Longitudinal Assessments of Risk Factors over 30 Years (CLARiFY) Diabetes Complications StudyR01DK129320 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FELDMAN, EVA LUCILLE · 2021 to 2025
$2.3M
National Health and Medical Research Council (NHMRC) 1137837NIDDK NIH HHS R01 DK129320NIH HHS R01DK129320
6 · The paper itself

Abstract

aimTo examine the associations between visceral adipose tissue (VAT) and brain structural measures at midlife and explore how these associations may be affected by age, sex and cardiometabolic factors.

methodsWe used abdominal and brain magnetic resonance imaging data from a population-based cohort of people at midlife in the UK Biobank. Regression modelling was applied to study associations of VAT volume with total brain volume (TBV), grey matter volume (GMV), white matter volume, white matter hyperintensity volume (WMHV) and total hippocampal volume (THV), and whether these associations were altered by age, sex or cardiometabolic factors.

resultsComplete data were available for 17 377 participants (mean age 63 years, standard deviation = 12, 53% female). Greater VAT was associated with lower TBV, GMV and THV (P < .001). We found an interaction between VAT and sex on TBV (P < .001), such that the negative association of VAT with TBV was greater in men (β = -2.89, 95% confidence interval [CI] -2.32 to -10.15) than in women (β = -1.32, 95% CI -0.49 to -3.14), with similar findings for GMV. We also found an interaction between VAT and age (but not sex) on WMHV (P < .001). The addition of other cardiometabolic factors or measures of physical activity resulted in little change to the models.

conclusionsVAT volume is associated with poorer brain health in midlife and this relationship is greatest in men and those at younger ages.

Indexed as

AgingBrainIntra-Abdominal FatMagnetic Resonance ImagingAdultAgedAge FactorsCohort StudiesFemaleGray MatterHumansMaleMiddle AgedOrgan SizeSex FactorsUnited Kingdombody compositioncohort studydatabase researchelderlyweight control

Identifiers

PMID38899555
PMCPMC11300145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.