Evidence map›Paper›PMID 38899385›Full record

ArticleAutophagy2024

An initial HOPS-mediated fusion event is critical for autophagosome transport initiation from the axon terminal.

Serena R Wisner, Madison Chlebowski, Amrita Mandal, Don Mai, Chris Stein, Ronald S Petralia, Ya-Xian Wang, Catherine M Drerup

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. NPC1 trafficking via VPS41-dependent LAMP carriers regulates endosomal cholesterol homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Serena R WisnerDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-5615-1623
Madison ChlebowskiDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.
Amrita MandalNational Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Don MaiDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.
Chris SteinDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.
Ronald S PetraliaAdvanced Imaging Core, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, MD, USA.
Ya-Xian WangAdvanced Imaging Core, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, MD, USA.
Catherine M DrerupDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-0219-3075

Funding

Regulation of retrograde cargo transport in axonsZIAHD008964 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DRERUP, CATHERINE M · 2017 to 2020
$2.8M
Neuroscience Training ProgramT32NS105602 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Ari Rosenberg · 2019 to 2026
$2.5M
SYNTACTIC REPRESENTATIONSP50DC000081 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GRODZINSKY, YOSEF · 1992 to 2001
$989k
Intramural NIH HHS ZIA HD008964NIDCD NIH HHS P50 DC000081NINDS NIH HHS T32 NS105602
6 · The paper itself

Abstract

In neurons, macroautophagy/autophagy is a frequent and critical process. In the axon, autophagy begins in the axon terminal, where most nascent autophagosomes form. After formation, autophagosomes must initiate transport to exit the axon terminal and move toward the cell body via retrograde transport. During retrograde transport these autophagosomes mature through repetitive fusion events. Complete lysosomal cargo degradation occurs largely in the cell body. The precipitating events to stimulate retrograde autophagosome transport have been debated but their importance is clear: disrupting neuronal autophagy or autophagosome transport is detrimental to neuronal health and function. We have identified the HOPS complex as essential for early autophagosome maturation and consequent initiation of retrograde transport from the axon terminal. In yeast and mammalian cells, HOPS controls fusion between autophagosomes and late endosomes with lysosomes. Using zebrafish strains with loss-of-function mutations in

Indexed as

AutophagosomesAutophagyAxonsVesicular Transport ProteinsZebrafishAnimalsBiological TransportEndosomesHumansLysosomesMembrane FusionNeuronsZebrafish ProteinsVesicular Transport ProteinsZebrafish Proteinsautophagyaxonal transportAxon terminallysosomeneuronVps18

Identifiers

PMID38899385
PMCPMC11423661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.