ArticleWorld journal of clinical cases2024
Iron and ferritin effects on intensive care unit mortality: A meta-analysis.
Article in World journal of clinical cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Association between iron homestasis and all-cause mortality in acute pancreatitis: A retrospective MIMIC-IV database analysis.Medicine · 2025Observational
- Exploratory Evaluation of Potential CRP and Ferritin Thresholds and Survival in Critically Ill Patients: A Pilot Prospective ICU Study.Journal of clinical medicine · 2025Article
- Development and validation of a diagnostic prediction model for acute liver injury in sepsis based on serum ferritin level.European journal of medical research · 2025Article
- Deciphering the iron enigma: Navigating the complexities of iron metabolism in critical illness.World journal of clinical cases · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of serum iron or ferritin parameters on mortality among critically ill patients is not well characterized.
aimTo determine the association between serum iron or ferritin parameters and mortality among critically ill patients.
methodsWeb of Science, Embase, PubMed, and Cochrane Library databases were searched for studies on serum iron or ferritin parameters and mortality among critically ill patients. Two reviewers independently assessed, selected, and abstracted data from studies reporting on serum iron or ferritin parameters and mortality among critically ill patients. Data on serum iron or ferritin levels, mortality, and demographics were extracted.
resultsNineteen studies comprising 125490 patients were eligible for inclusion. We observed a slight negative effect of serum ferritin on mortality in the United States population [relative risk (RR) 1.002; 95%CI: 1.002-1.004). In patients with sepsis, serum iron had a significant negative effect on mortality (RR = 1.567; 95%CI: 1.208-1.925).
conclusionThis systematic review presents evidence of a negative correlation between serum iron levels and mortality among patients with sepsis. Furthermore, it reveals a minor yet adverse impact of serum ferritin on mortality among the United States population.
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