Evidence map›Paper›PMID 38899300›Full record

ArticleWorld journal of clinical cases2024

Thoracic giant cell tumor after two total

Hai-Feng Liang, Hao Xu, Meng-Na Zhan, Jian Xiao, Juan Li, Qin-Ming Fei

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Article in World journal of clinical cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Hai-Feng LiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Hao XuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Meng-Na ZhanDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Jian XiaoDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Juan LiDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Qin-Ming FeiDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFor patients with acute paraplegia caused by spinal giant cell tumor (GCT) who require emergency decompressive surgery, there is still a lack of relevant reports on surgical options. This study is the first to present the case of an acute paraplegic patient with a thoracic spinal GCT who underwent an emergency total CASE SUMMARY: A 27-year-old female patient who underwent single-level TES in an emergency presented with sudden severe back pain and acute paraplegia due to a thoracic spinal tumor. After emergency TES, the patient's spinal cord function recovered, and permanent paralysis was avoided. The postoperative histopathological examination revealed that the excised neoplasm was a rare GCT. Unfortunately, the tumor recurred 9 months after the first surgery. After 12 months of denosumab therapy, the tumor size was reduced, and tumor calcification. To prevent recurrent tumor progression and provide a possible cure, a three-level TES was performed again. The patient returned to an active lifestyle 1 month after the second surgery, and no recurrence of GCT was found at the last follow-up.

conclusionThis patient with acute paraplegia underwent TES twice, including once in an emergency, and achieved good therapeutic results. TES in emergency surgery is feasible and safe when conditions permit; however, it may increase the risk of tumor recurrence.

Indexed as

Case reportDenosumab therapyEmergency treatmentGiant cell tumorThoracic spineTotal en bloc spondylectomy

Identifiers

PMID38899300
PMCPMC11185343

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