Evidence map›Paper›PMID 38899268›Full record

ArticleCureus2024

Analysis of Genes Involved in Oxidative Stress and Iron Metabolism in Heart Failure: A Step Forward in Risk Stratification.

Pedro X Silva, Laura Aguiar, Marcos Gaspar, Paula Faustino, Luiz M Falcão, Mário Barbosa, Manuel Bicho, Ângela Inácio

Abstract read
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Association Between Antioxidant Enzyme Polymorphisms with Type 2 Diabetes Mellitus in Jazan Province.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pedro X SilvaGenetics Laboratory, Faculty of Medicine of the University of Lisbon, Lisbon, PRT.
Laura AguiarAssociate Laboratory TERRA, Environmental Health Institute, Faculty of Medicine of the University of Lisbon, Lisbon, PRT.
Marcos GasparGenetics Laboratory, Faculty of Medicine of the University of Lisbon, Lisbon, PRT.
Paula FaustinoDepartment of Human Genetics, National Institute of Health Dr. Ricardo Jorge, Lisbon, PRT.
Luiz M FalcãoDepartment of Genetics, Bento da Rocha Cabral Institute for Scientific Research, Lisbon, PRT.
Mário BarbosaDepartment of Medicine, Hospital Lusíadas Lisboa, Lisbon, PRT.
Manuel BichoGenetics Laboratory, Faculty of Medicine of the University of Lisbon, Lisbon, PRT.
Ângela InácioGenetics Laboratory, Faculty of Medicine of the University of Lisbon, Lisbon, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHeart failure (HF) is a clinical syndrome characterized by cardinal symptoms that may be accompanied by signs. It results from structural and/or functional abnormalities of the heart leading to elevated intracardiac pressures and/or inadequate cardiac output at rest and/or during exercise. The prevalence of iron deficiency and anemia justifies the current guidelines recommendation of screening. Genes

methodsWe used a database of 389 individuals, 143 HF patients, and 246 healthy controls. Genotypes were characterized through PAGE electrophoresis, PCR, PCR-RFLP, and multiplex-ARMS. Data analysis was performed with the SPSS® 26.0 software (IBM Corp., Armonk, NY).

resultsWe observed a significant association between the

conclusionWe concluded that genes

Indexed as

epistasisgeneticsheart failureiron metabolismoxidative stresspersonalized medicine

Identifiers

PMID38899268
PMCPMC11186693

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.