Evidence map›Paper›PMID 38898992›Full record

ArticleiMeta2024

Cardiovascular disease therapeutics via engineered oral microbiota: Applications and perspective.

Wenyu Zhen, Zifei Wang, Qing Wang, Wansu Sun, Rui Wang, Wenhao Zhang, Yulong Zhang, Wengang Qin, Bang Li, Qingqing Wang and 14 more

Abstract read
In one paragraph

Article in iMeta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Wenyu ZhenKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Zifei WangKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Qing WangKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Wansu SunDepartment of Stomatology The First Affiliated Hospital of Anhui Medical University Hefei China.
Rui WangKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Wenhao ZhangKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Yulong ZhangKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Wengang QinThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei China.
Bang LiKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Qingqing WangKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Biao HongKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Yicheng YangState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Pediatric Cardiac Surgery Center, Fuwai Hospital Chinese Academy of Medical Sciences, and Peking Union Medical College Beijing China.
Jing XuState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Pediatric Cardiac Surgery Center, Fuwai Hospital Chinese Academy of Medical Sciences, and Peking Union Medical College Beijing China.
Siyu MaDepartment of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing China.
Ming DaDepartment of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing China.
Linfei FengDepartment of Stomatology The First Affiliated Hospital of Anhui Medical University Hefei China.
Xiaodong ZangThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei China.
Xuming MoDepartment of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing China.
Xiaoyu SunKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Mingyue WuKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Junji XuLaboratory of Tissue Regeneration and Immunology, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Department of Periodontics, School of Stomatology Capital Medical University Beijing China.
Jianguang XuKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.
Yuan HuangState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Pediatric Cardiac Surgery Center, Fuwai Hospital Chinese Academy of Medical Sciences, and Peking Union Medical College Beijing China.ORCID 0000-0002-1420-8932
Hengguo ZhangKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology Anhui Medical University Hefei China.ORCID 0000-0002-4438-8348

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineering bacteria are considered as a potential treatment for cardiovascular diseases and related risk factors. Oral bacteria are closely related to the occurrence and development of cardiovascular diseases, and their engineering has broad prospects and potential in the treatment of cardiovascular diseases. Oral pathogenic bacteria undergo protein and genetic engineering, including the incorporation of exogenous plasmids to yield therapeutic effects; genetically engineered oral probiotics can be harnessed to secrete cytokines and reactive oxygen species, offering novel therapeutic avenues for cardiovascular diseases.

Indexed as

cardiovascular diseasesengineered microbiotaoral microbiota

Identifiers

PMID38898992
PMCPMC11183164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.