Evidence map›Paper›PMID 38898988›Full record

ArticleiMeta2024

The feasibility of using pathobiome strains as live biotherapeutic products for human use.

Pengfei Jin, Xiong Lin, Wenfeng Xu, Kangning Li, Xiaoxiao Zhao, Sirui Guo, Zinan Zhao, Lujie Jiang, Feng Liao, Longgang Chang and 5 more

Abstract read
In one paragraph

Article in iMeta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pengfei JinDepartment of Pharmacy Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences; Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital) Beijing China.
Xiong LinShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Wenfeng XuDepartment of Pharmacy Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences; Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital) Beijing China.
Kangning LiShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Xiaoxiao ZhaoShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Sirui GuoDepartment of Pharmacy Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences; Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital) Beijing China.
Zinan ZhaoDepartment of Pharmacy Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences; Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital) Beijing China.
Lujie JiangShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Feng LiaoShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Longgang ChangShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Min WangShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Yanmin LiuShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Shaolei HuangShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.
Zhangran ChenShenzhen Wedge Microbiology Research Co., Ltd. Shenzhen China.ORCID 0000-0001-6292-7029
Fusui JiDepartment of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evaluation of pathobiome strains should be conducted at the strain level, involving the identification of the functional genes, while considering the impact of ecological niche and drug interactions. The safety, efficacy, and quality management of live biotherapeutic products (LBPs), especially pathobiome strains, have certain peculiarities. Promising development methods include the recombinant LBP and active metabolites.

Identifiers

PMID38898988
PMCPMC11183195

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.