Evidence map›Paper›PMID 38898950›Full record

ArticleACS pharmacology & translational science2024

Unlocking the Therapeutic Potential: Sitagliptin's Multifaceted Approach in Drug-Resistant Epilepsy through a Novel Mechanism Inhibiting Protein Kinase C-γ and a Long-Term Potentiation Pathway.

Harvinder Singh, Anupam Raja, Arushi Chauhan, Ashish Jain, Ajay Prakash, Alka Bhatia, Pramod Avti, Bikash Medhi

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Harvinder SinghDepartment of Pharmacology, PGIMER, Chandigarh 160012, India.
Anupam RajaDepartment of Pharmacology, PGIMER, Chandigarh 160012, India.
Arushi ChauhanDepartment of Biophysics, PGIMER, Chandigarh 160012, India.
Ashish JainDepartment of Pharmacology, PGIMER, Chandigarh 160012, India.
Ajay PrakashDepartment of Pharmacology, PGIMER, Chandigarh 160012, India.
Alka BhatiaDepartment of Experimental Medicine and Biotechnology, PGIMER, Chandigarh 160012, India.
Pramod AvtiDepartment of Biophysics, PGIMER, Chandigarh 160012, India.ORCID https://orcid.org/0000-0001-5603-4523
Bikash MedhiDepartment of Pharmacology, PGIMER, Chandigarh 160012, India.ORCID https://orcid.org/0000-0002-4017-641X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-resistant epilepsy is a prominent challenge in chronic neurological disorders. Valproate, commonly used to treat epilepsy, can fail due to various side effects and interactions, necessitating the exploration of alternative treatments. Our study primarily investigated sitagliptin's potential as a therapeutic agent for drug-resistant epilepsy. Employing computational modeling and enzyme assay testing, three lead compounds, emixustat, sitagliptin, and distigmine bromide, were evaluated against the target enzyme protein kinase C-γ.

Identifiers

PMID38898950
PMCPMC11184596

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.