Evidence map›Paper›PMID 38898493›Full record

ArticleJournal of nanobiotechnology2024

Tumor microenvironment responsive nano-herb and CRISPR delivery system for synergistic chemotherapy and immunotherapy.

Yuanyuan Jia, Yuhui Yao, Lingyao Fan, Qiqing Huang, Guohao Wei, Peiliang Shen, Jia Sun, Gaoshuang Zhu, Zhaorui Sun, Chuandong Zhu and 1 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuanyuan Jia *The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Yuhui Yao *Department of Oncology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China.
Lingyao FanDepartment of Oncology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China.
Qiqing HuangThe Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Guohao WeiDepartment of Oncology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China.
Peiliang ShenThe Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Jia SunThe Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Gaoshuang ZhuThe Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhaorui SunDepartment of Emergency Medicine, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210002, China. sunzhr84@163.com.
Chuandong ZhuDepartment of Oncology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China. zhucd@njucm.edu.cn.
Xin HanThe Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China. xhan0220@njucm.edu.cn.

Funding

Key Project of Nanjing Medical Science and Technology Development Project ZKX23037Key Project of Talent Support Plan of Nanjing Second Hospital RCZD202302Nanjing University of Traditional Chinese Medicine Natural Science Foundation XRZ2021078National Natural Science Foundation of China 82203337Natural Science Foundation of the Higher Education Institutions of Jiangsu Province 22KJB320017Supporting project of Nanjing University of Chinese Medicine to NSFC XPT82203337The Graduate Research & Practice Innovation Program of Jiangsu Province KYCX23_2181the medical scientific research project of Jiangsu Health Commission M2020055
6 · The paper itself

Abstract

Chemoresistance remains a significant challenge for effective breast cancer treatment which leads to cancer recurrence. CRISPR-directed gene editing becomes a powerful tool to reduce chemoresistance by reprogramming the tumor microenvironment. Previous research has revealed that Chinese herbal extracts have significant potential to overcome tumor chemoresistance. However, the therapeutic efficacy is often limited due to their poor tumor targeting and in vivo durability. Here we have developed a tumor microenvironment responsive nanoplatform (H-MnO

Indexed as

DoxorubicinImmunotherapyTumor MicroenvironmentAnimalsAntineoplastic AgentsBreast NeoplasmsCell Line, TumorClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsDrug Delivery SystemsDrug Resistance, NeoplasmFemaleGene EditingHumansManganese CompoundsMiceAntineoplastic AgentsDoxorubicinManganese Compoundsmanganese dioxideOxidesCRISPR-Cas 9Doxorubicin (DOX)ImmunotherapyIsoliquiritigenin (ISL)Protein tyrosine phosphatase non-receptor type 2 (PTPN2)Synergistic therapy

Identifiers

PMID38898493
PMCPMC11186293

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.