ArticleNature2024
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 85 papers.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed.
- Effect of inhaled interferon-β1a on SARS-CoV-2 diversity and evolution.Microbiology spectrum · 2026Trial
- Safety, tolerability, and efficacy of intranasally-administered detoxified LTh(αK) in mild-to-moderate COVID-19 patients: A randomized, double-blinded, placebo-controlled phase 2 study.Human vaccines & immunotherapeutics · 2024Trial
- Monocyte Activation Drives Atrial Fibrillation in Hypertension.Cardiovascular drugs and therapy · 2026Article
- Utility of Nasopharyngeal Aspirate Over Other Upper Airway Sampling Approaches for Cellular Immunology During Respiratory Viral Infection.The Journal of infectious diseases · 2026Article
- Type I IFN dynamics orchestrate protective ICAM1iScience · 2026Article
- Heterogeneity of Immunological, Coagulation and Complement Clustering to Viral Challenge and Clinical Relevance.International journal of molecular sciences · 2026Article
- Article
- Renaissance of antiviral CD8Nature reviews. Immunology · 2026Review
- Cleavage of TOM1 by the SARS-CoV-2 main protease NSP5 prevents autophagic degradation of viral envelope.Journal of virology · 2026Article
- The challenge and promise of studying human antigen-specific T cells.Nature reviews. Immunology · 2026Review
- Review
- Innate immune responsiveness predicts enhanced cellular immunity and symptomatic disease after controlled human influenza infection.Nature medicine · 2026Article
- Longitudinal single-cell and TCR repertoire profiling characterizes clonal entrapment in patients with pMMR/MSS locally advanced rectal cancer.Cell discovery · 2026Article
- Extra gene coding capacity of SARS-CoV-2 provides a virus engineering platform for in vitro and in vivo applications.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Quantum Dot-Based Dual-Fluorescence Aptasensing Platform Using Interface-Engineered MXene for Multiplex Protein Detection.Sensors (Basel, Switzerland) · 2026Article
- Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model.Cell reports. Medicine · 2026Article
- Coordinated immune-epithelial dynamics in the nasal epithelium protect against respiratory virus infection.bioRxiv : the preprint server for biology · 2026Article
- Standardizing antiviral response metrics for mono- and combination therapies in acute, chronic and latent viral infections.Virology journal · 2026Review
- Pathogen-specific host responses define distinct pneumonia endotypes in the human lung.bioRxiv : the preprint server for biology · 2026Article
- Abortive infection: T cells as early, antibody-independent defenders.Nature reviews. Immunology · 2026Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
44 authors.
Rik G H Lindeboom *Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. r.lindeboom@nki.nl.ORCID 0000-0002-3660-504X
Kaylee B Worlock *UCL Respiratory, Division of Medicine, University College London, London, UK.ORCID 0000-0002-5656-7634
Lisa M DratvaWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-2873-6787
Masahiro YoshidaUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID 0000-0002-3521-5322
David ScobieResearch Department of Infection, Division of Infection and Immunity, University College London, London, UK.
Helen R WagstaffeDepartment of Infectious Disease, Imperial College London, London, UK.ORCID 0000-0002-4462-7484
Laura RichardsonWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-8075-3816
Anna Wilbrey-ClarkWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Josephine L BarnesUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID 0000-0001-9938-3176
Lorenz KretschmerWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0003-0987-8429
Krzysztof PolanskiWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-2586-9576
Jessica Allen-HyttinenUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID 0000-0003-4644-0362
Puja MehtaUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID 0000-0001-9459-9306
Dinithi SumanaweeraWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Jacqueline M BoccacinoWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0001-6813-5217
Waradon SungnakWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-0136-4960
Rasa ElmentaiteWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0001-7366-5466
Ni HuangWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0001-8849-038X
Lira MamanovaWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Rakesh KapugeWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0009-0001-3394-0387
Liam BoltWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0001-7293-0774
Elena PrigmoreWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0001-8870-0316
Ben KillingleyDepartment of Infectious Diseases, University College London Hospital, London, UK.
Mariya KalinovahVIVO, London, UK.
Maria MayerhVIVO, London, UK.
Alison BoyershVIVO, London, UK.
Alex MannhVIVO, London, UK.
Leo SwadlingDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.ORCID 0000-0002-0537-6715
Maximillian N J WoodallUCL Great Ormond Street Institute of Child Health, London, UK.
Samuel EllisUCL Great Ormond Street Institute of Child Health, London, UK.
Claire M SmithUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-8913-0009
Vitor H TeixeiraUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID 0000-0003-0090-861X
Sam M JanesUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID 0000-0002-6634-5939
Rachel C ChambersUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID 0000-0003-1370-9417
Muzlifah HaniffaWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-3927-2084
Andrew CatchpolehVIVO, London, UK.
Robert HeydermanResearch Department of Infection, Division of Infection and Immunity, University College London, London, UK.ORCID 0000-0003-4573-449X
Mahdad NoursadeghiResearch Department of Infection, Division of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-4774-0853
Benny ChainResearch Department of Infection, Division of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-7417-3970
Andreas MayerResearch Department of Infection, Division of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-6643-7622
Kerstin B MeyerWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0001-5906-1498
Christopher ChiuDepartment of Infectious Disease, Imperial College London, London, UK.ORCID 0000-0003-0914-920X
Marko Z NikolićUCL Respiratory, Division of Medicine, University College London, London, UK. m.nikolic@ucl.ac.uk.ORCID 0000-0001-6304-6848
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. sat1003@cam.ac.uk.ORCID 0000-0002-6294-6366
Funding
Medical Research Council MC_PC_17230Medical Research Council MR/W025051/1Wellcome Trust
Abstract
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited
Indexed as
COVID-19MultiomicsSARS-CoV-2Single-Cell AnalysisEpithelial CellsFemaleGene Expression ProfilingHLA-DQ AntigensHumansInterferonsMacrophagesMaleNasopharynxTime FactorsT-LymphocytesVirus ReplicationHLA-DQA2 antigenHLA-DQ AntigensInterferons
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.