ArticleNature aging2024
Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention.
Article in Nature aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07444073 (Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock), which is not on this map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock
Who cites it
59 citing papers in PubMed.
- The CALERIE Genomic Data Resource.Nature aging · 2025Trial
- Predicting and finding geroprotective compounds through modulating conserved longevity-associated aging modules.Science advances · 2026Article
- Cluster-derived immunometabolic profiles: association with glycemic dysregulation in elderly postmenopausal women.Endocrine · 2026Article
- Machine Learning-Integrated Metabolomics for Precision Pharmacotherapy: Advances, Challenges, and Clinical Translation.Metabolites · 2026Review
- Sex-specific trajectories of nonlinear immune aging at single-cell level.Nature communications · 2026Article
- A clinically practical aging clock (physical clock) for healthy aging: development, validation, and application for health assessment and intervention.Science China. Life sciences · 2026Article
- Estimation of biological age and age-related outcomes with easily accessible parameters in Chinese.GeroScience · 2026Article
- Epigenetic mechanisms of gingival aging: biological basis, periodontal implications, and therapeutic perspectives.Odontology · 2026Review
- Hierarchical endpoints and win statistics for geromedicine trials.Nature aging · 2026Review
- Network-driven discovery of repurposable drugs targeting hallmarks of aging.Nature aging · 2026Article
- Random Attention Mechanism for Deep Quality Modeling and Online Prediction in Chemical Processes.ACS omega · 2026Article
- Data and knowledge-driven imaging biomarkers for lumbar aging and degenerative risk stratification monitoring.NPJ digital medicine · 2026Article
- G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles.BMC immunology · 2026Article
- Liver Aging Index: A Noninvasive Score for Liver Biological Aging and Liver-Related Outcomes in Multicohorts.Aging cell · 2026Article
- The gut microbiome and ageing trajectories: mechanisms and clinical implications.Nature reviews. Endocrinology · 2026Review
- Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.Aging cell · 2026Article
- Biological age acceleration and extrahepatic multimorbidity in U.S. adults with metabolic dysfunction-associated steatotic liver disease: a national cross-sectional study.Clinical and experimental hepatology · 2026Article
- Amino acid-based biological age clock and its implications for human health and aging.Nature communications · 2026Article
- Foundations of Gerophysics.Aging · 2026Article
- A Multimodal Framework for Organ- and Cell-Resolved Biological Aging and Longevity Intervention Discovery.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Clocks that measure biological age should predict all-cause mortality and give rise to actionable insights to promote healthy aging. Here we applied dimensionality reduction by principal component analysis to clinical data to generate a clinical aging clock (PCAge) identifying signatures (principal components) separating healthy and unhealthy aging trajectories. We found signatures of metabolic dysregulation, cardiac and renal dysfunction and inflammation that predict unsuccessful aging, and we demonstrate that these processes can be impacted using well-established drug interventions. Furthermore, we generated a streamlined aging clock (LinAge), based directly on PCAge, which maintains equivalent predictive power but relies on substantially fewer features. Finally, we demonstrate that our approach can be tailored to individual datasets, by re-training a custom clinical clock (CALinAge), for use in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study of caloric restriction. Our analysis of CALERIE participants suggests that 2 years of mild caloric restriction significantly reduces biological age. Altogether, we demonstrate that this dimensionality reduction approach, through integrating different biological markers, can provide targets for preventative medicine and the promotion of healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.