ArticleNature immunology2024
Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans.
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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Who cites it
25 citing papers in PubMed.
- Specificity, frequency, and phenotype of citrullinated-specific T cells vary with disease activity in rheumatoid arthritis.JCI insight · 2026Article
- Beyond B cell helpers: diverse roles of peripheral helper T cells.International immunology · 2026Review
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer.Nature communications · 2026Article
- Granzyme K CD8⁺ T cells with tissue-resident features promote intestinal inflammation in patients with Crohn's disease.Experimental & molecular medicine · 2026Article
- A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation.Nature immunology · 2026Article
- Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation.Experimental & molecular medicine · 2026Article
- Tannins as Therapeutic Agents for Ulcerative Colitis: Mechanisms and Prospects in Regulating Gut Inflammatory-Oxidative Homeostasis.Molecules (Basel, Switzerland) · 2026Review
- TGF-β signaling mediates crosstalk between CD8Journal of biomedical science · 2026Article
- Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice.Nature communications · 2026Article
- Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis.Science immunology · 2026Article
- Stem-like CD4 T cells in tumors: an emerging framework for antitumor immunity.Frontiers in immunology · 2026Review
- Dual-pathway mechanisms of plant-derived polysaccharides in ulcerative colitis: integrative roles of microbiota modulation, immune regulation, and barrier restoration.Frontiers in pharmacology · 2026Review
- Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy.Cellular & molecular immunology · 2025Review
- Immune regeneration: implications for cancer immunotherapy and beyond.The Journal of clinical investigation · 2025Review
- OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.The Journal of clinical investigation · 2025Article
- Common mechanisms of Gut microbe-based strategies for the treatment of intestine-related diseases: based on multi-target interactions with the intestinal barrier.Cell communication and signaling : CCS · 2025Review
- Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset.Nature communications · 2025Article
- Phenotypic and functional dysregulations of CD8 + T Cells in myasthenia gravis.Clinical and experimental medicine · 2025Article
- RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease.Cell discovery · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Yingcong Li *La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0746-0531
Ciro Ramírez-Suástegui *La Jolla Institute for Immunology, La Jolla, CA, USA.
Richard Harris *School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0002-1658-2979
Francisco Emmanuel Castañeda-CastroLa Jolla Institute for Immunology, La Jolla, CA, USA.
Gabriel AscuiLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6837-3194
Tamara Pérez-JeldresDepartment of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Alejandro DiazDepartment of Gastroenterology, Hospital San Borja Arriarán, Santiago, Chile.
Carla MorongDepartment of Gastroenterology, Hospital San Borja Arriarán, Santiago, Chile.
Daniel A GilesLa Jolla Institute for Immunology, La Jolla, CA, USA.
Jiani ChaiLa Jolla Institute for Immunology, La Jolla, CA, USA.
Gregory SeumoisLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8164-6852
Tilman Sanchez-ElsnerDepartment of Gastroenterology, University Hospital Southampton NHS FT, Southampton, UK.
Fraser CummingsSchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Mitchell KronenbergLa Jolla Institute for Immunology, La Jolla, CA, USA. mitch@lji.org.ORCID http://orcid.org/0000-0001-6318-6445
Pandurangan VijayanandLa Jolla Institute for Immunology, La Jolla, CA, USA. vijay@lji.org.ORCID http://orcid.org/0000-0001-7067-9723
Funding
Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI MCGOVERN, DERMOT PATRICK · 1992 to 2020
$31.1MNovaSeq5000 High Throughput SequencerS10OD025052 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SEUMOIS, GREGORY · 2018 to 2018
$832kSuper-resolution confocal microscopeS10OD021831 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2017 to 2017
$566kFACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514kThe role of GPR183 in Inflammatory Bowel Disease pathogenesisF32AI140581 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI GILES, DANIEL AARON · 2018 to 2019
$89kNCRR NIH HHS S10 RR027366NIAID NIH HHS F32 AI140581NIDDK NIH HHS P01 DK046763NIH HHS S10 OD021831NIH HHS S10 OD025052U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK46763
Abstract
To understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from patients with UC and controls. Here we identified colonic CD4
Indexed as
Colitis, UlcerativeHepatocyte Nuclear Factor 1-alphaAdoptive TransferAdultAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesColonDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseProto-Oncogene Proteins c-bcl-6
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.