Evidence map›Paper›PMID 38898119›Full record

ArticleScientific reports2024

Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells.

Hideyuki Yamada, Mamoru Takada, Dhaval Ghone, Muhan Yu, Takeshi Nagashima, Hiroshi Fujimoto, Junta Sakakibara, Yoshie Hasegawa, Shintaro Takao, Akimitsu Yamada and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Hideyuki YamadaDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan.
Mamoru TakadaDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan. mamoru@chiba-u.jp.
Dhaval GhoneBiophysics Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.
Muhan YuDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan.
Takeshi NagashimaDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan.
Hiroshi FujimotoDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan.
Junta SakakibaraDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan.
Yoshie HasegawaDepartment of Breast Surgery, Hachinohe City Hospital, Hachinohe, Aomori, Japan.
Shintaro TakaoDepartment of Breast Surgery, Konan Medical Center, Kobe, Hyogo, Japan.
Akimitsu YamadaDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
Kazutaka NaruiDepartment of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
Takashi IshikawaDepartment of Breast Oncology and Surgery, Tokyo Medical University, Shinjuku, Tokyo, Japan.
Aussie SuzukiBiophysics Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.
Masayuki OtsukaDepartment of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan.

Funding

Chromosome dynamics and organizations necessary for faithful chromosome segregationR35GM147525 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Aussie Suzuki · 2022 to 2026
$2.5M
Japan Society for the Promotion of Science JP21K08638JSPS KAKENHI JP22K08727NIGMS NIH HHS R35 GM147525NIH grant R35GM147525
6 · The paper itself

Abstract

Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited reports explore ERI's effects on the cGAS-STING pathway. Additionally, the nuclear presence of cGAS remains poorly understood. This study uniquely delves into ERI's impact on both the cytosolic cGAS-STING pathway and nuclear cGAS. ERI enhances nuclear localization of cGAS, resulting in hyper-activation of the cGAS-STING pathway in triple-negative breast cancer cells. Reduction of cGAS heightened both cell proliferation and ERI sensitivity. In clinical data using ERI in a neo-adjuvant setting, patients with low cGAS cases exhibited reduced likelihood of achieving pathological complete response after ERI treatment. These findings illuminate the potential of cGAS and IFNβ as predictive biomarkers for ERI sensitivity, providing valuable insights for personalized breast cancer treatment strategies.

Indexed as

Cell NucleusFuransKetonesNucleotidyltransferasesTriple Negative Breast NeoplasmsCell Line, TumorCell ProliferationCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseFemaleHumansMembrane ProteinsPolyether PolyketidesSignal TransductionSTING ProteincGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseeribulinFuransKetonesMembrane ProteinsNucleotidyltransferasesPolyether PolyketidesSTING1 protein, humanSTING Protein

Identifiers

PMID38898119
PMCPMC11187130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.