Evidence map›Paper›PMID 38898027›Full record

ArticleCell death & disease2024

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.

Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan, Zhizhong Li, Guodong Sun, Zhongjun Dong, Meixiang Yang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Peiran Feng *Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People's Hospital), Jinan University, Heyuan, 517000, China.
Liang Luo *The Biomedical Translational Research Institute, School of Medicine, Jinan University, Guangzhou, 510632, China.
Quanli Yang *Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital（Zhuhai Clinical Medical College of Jinan University）, Jinan University, Zhuhai, 519000, China.
Wanqing Meng *The Biomedical Translational Research Institute, School of Medicine, Jinan University, Guangzhou, 510632, China.
Zerong GuanThe Biomedical Translational Research Institute, School of Medicine, Jinan University, Guangzhou, 510632, China.
Zhizhong LiGuangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People's Hospital), Jinan University, Heyuan, 517000, China.
Guodong SunGuangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People's Hospital), Jinan University, Heyuan, 517000, China.
Zhongjun DongThe First Affiliated Hospital of Anhui Medical University and Institute for Clinical Immunology, Anhui Medical University, 230032, Anhui, China. dongzj@mail.tsinghua.edu.cn.ORCID 0000-0002-2155-231X
Meixiang YangGuangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People's Hospital), Jinan University, Heyuan, 517000, China. mxyang@jnu.edu.cn.ORCID 0000-0003-4547-3170

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32000615National Natural Science Foundation of China (National Science Foundation of China) 82071737National Natural Science Foundation of China (National Science Foundation of China) 82271754National Natural Science Foundation of China (National Science Foundation of China) 82301974Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2020A1515111081Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2023A1515012582
6 · The paper itself

Abstract

Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining the fate and function of NK cells. In this study, we made an important discovery regarding the involvement of the Hippo kinases Mst1 and Mst2 as novel regulators in maintaining mouse NK cell homeostasis. The presence of high Mst1 and Mst2 (Mst1/2) activity in NK cells is essential for their proper development, survival and function in a canonical Hippo signaling independent mode. Mechanistically, Mst1/2 induce cellular quiescence by regulating the processes of proliferation and mitochondrial metabolism, thereby ensuring the development and survival of NK cells. Furthermore, Mst1/2 effectively sense IL-15 signaling and facilitate the activation of pSTAT3-TCF1, which contributes to NK cell homeostasis. Overall, our investigation highlights the crucial role of Mst1/2 as key regulators in metabolic reprogramming and transcriptional regulation for mouse NK cell survival and function, emphasizing the significance of cellular quiescence during NK cell development and functional maturation.

Indexed as

HomeostasisKiller Cells, NaturalProtein Serine-Threonine KinasesSerine-Threonine Kinase 3AMP-Activated Protein KinasesAnimalsCell ProliferationCell SurvivalHepatocyte Growth FactorHippo KinasesHippo Signaling PathwayHumansInterleukin-15MiceMice, Inbred C57BLMitochondriaAMP-Activated Protein KinasesHepatocyte Growth FactorHippo KinasesInterleukin-15macrophage stimulating proteinProtein Serine-Threonine KinasesProto-Oncogene ProteinsSerine-Threonine Kinase 3STAT3 Transcription FactorStk11 protein, mouseStk3 protein, mouseStk4 protein, mouse

Identifiers

PMID38898027
PMCPMC11187177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.