Evidence map›Paper›PMID 38898021›Full record

ArticleNature communications2024

The association of maternal factors with the neonatal microbiota and health.

Bin Zhu, David J Edwards, Katherine M Spaine, Laahirie Edupuganti, Andrey Matveyev, Myrna G Serrano, Gregory A Buck

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bin ZhuMicrobiology & Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.ORCID http://orcid.org/0000-0003-2829-2925
David J EdwardsCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Katherine M SpaineMicrobiology & Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Laahirie EdupugantiMicrobiology & Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Andrey MatveyevMicrobiology & Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Myrna G SerranoMicrobiology & Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.ORCID http://orcid.org/0000-0003-4327-0193
Gregory A BuckMicrobiology & Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA. gregory.buck@vcuhealth.org.ORCID http://orcid.org/0000-0003-4621-3987

Funding

A Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54HD080784 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2014 to 2015
$8.2M
Longitudinal Multiomics Microbial Profiling in Healthy and Disease IndividualsU54DK102556 · NIDDK · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P., WEINSTOCK, GEORGE M · 2014 to 2015
$7.7M
The Vaginal Microbiome: Disease, Genetics and the EnvironmentUH3AI083263 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2010 to 2012
$6.8M
The Influence of HPV on Preterm Birth via Immunomodulation of the MicrobiomeR01HD092415 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2017 to 2021
$3.6M
A Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54DE023786 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2013 to 2014
$3.0M
The Vaginal Microbiome and Racial Disparity in Preterm DeliveryR01MD011504 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ENGEL, STEPHANIE · 2017 to 2020
$2.6M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01HD092415Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) U54HD080784Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) UH3AI083263NIAID NIH HHS UH3 AI083263NICHD NIH HHS R01 HD092415NICHD NIH HHS U54 HD080784NIDCR NIH HHS U54 DE023786NIDDK NIH HHS U54 DK102556NIMHD NIH HHS R01 MD011504
6 · The paper itself

Abstract

The human microbiome plays a crucial role in human health. However, the influence of maternal factors on the neonatal microbiota remains obscure. Herein, our observations suggest that the neonatal microbiotas, particularly the buccal microbiota, change rapidly within 24-48 h of birth but begin to stabilize by 48-72 h after parturition. Network analysis clustered over 200 maternal factors into thirteen distinct groups, and most associated factors were in the same group. Multiple maternal factor groups were associated with the neonatal buccal, rectal, and stool microbiotas. Particularly, a higher maternal inflammatory state and a lower maternal socioeconomic position were associated with a higher alpha diversity of the neonatal buccal microbiota and beta diversity of the neonatal stool microbiota was influenced by maternal diet and cesarean section by 24-72 h postpartum. The risk of admission of a neonate to the newborn intensive care unit was associated with preterm birth as well as higher cytokine levels and probably higher alpha diversity of the maternal buccal microbiota.

Indexed as

FecesMicrobiotaAdultCesarean SectionFemaleGastrointestinal MicrobiomeHumansInfant, NewbornMaleMouthPregnancyPremature BirthRectum

Identifiers

PMID38898021
PMCPMC11187136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.