Evidence map›Paper›PMID 38898009›Full record

ArticleTranslational psychiatry2024

Chronic post-COVID neuropsychiatric symptoms persisting beyond one year from infection: a case-control study and network analysis.

Steven Wai Ho Chau, Timothy Mitchell Chue, Rachel Ngan Yin Chan, Yee Lok Lai, Paul W C Wong, Shirley Xin Li, Yaping Liu, Joey Wing Yan Chan, Paul Kay-Sheung Chan, Christopher K C Lai and 2 more

Abstract read
In one paragraph

Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Steven Wai Ho ChauDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. stevenwaihochau@cuhk.edu.hk.ORCID 0000-0002-2986-8677
Timothy Mitchell ChueDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Rachel Ngan Yin ChanDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Yee Lok LaiDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0009-0004-1002-8805
Paul W C WongDepartment of Social Work and Social Administration, Faculty of Social Science, The University of Hong Kong, Hong Kong, China.
Shirley Xin LiDepartment of Psychology, Faculty of Social Science, The University of Hong Kong, Hong Kong, China.
Yaping LiuDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-2015-8775
Joey Wing Yan ChanDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-2692-2666
Paul Kay-Sheung ChanDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Christopher K C LaiDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0001-8591-5944
Thomas W H LeungDivision of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Yun Kwok WingDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-5745-5474

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our study aims to delineate the phenotypes of chronic neuropsychiatric symptoms among adult subjects recovering from their first COVID that occurred more than one year ago. We also aim to explore the clinical and socioeconomic risk factors of having a high loading of chronic neuropsychiatric symptoms. We recruited a post-COVID group who suffered from their first pre-Omicron COVID more than a year ago, and a control group who had never had COVID. The subjects completed app-based questionnaires on demographic, socioeconomic and health status, a COVID symptoms checklist, mental and sleep health measures, and neurocognitive tests. The post-COVID group has a statistically significantly higher level of fatigue compared to the control group (p < 0.001). Among the post-COVID group, the lack of any COVID vaccination before the first COVID and a higher level of material deprivation before the COVID pandemic predicts a higher load of chronic post-COVID neuropsychiatric symptoms. Partial correlation network analysis suggests that the chronic post-COVID neuropsychiatric symptoms can be clustered into two major (cognitive complaints -fatigue and anxiety-depression) and one minor (headache-dizziness) cluster. A higher level of material deprivation predicts a higher number of symptoms in both major clusters, but the lack of any COVID vaccination before the first COVID only predicts a higher number of symptoms in the cognitive complaints-fatigue cluster. Our result suggests heterogeneity among chronic post-COVID neuropsychiatric symptoms, which are associated with the complex interplay of biological and socioeconomic factors.

Indexed as

COVID-19AdultAnxietyCase-Control StudiesChronic DiseaseDepressionFatigueFemaleHumansMaleMiddle AgedNeuropsychological TestsPost-Acute COVID-19 SyndromeRisk FactorsSARS-CoV-2Socioeconomic Factors

Identifiers

PMID38898009
PMCPMC11187160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.