ArticleNature communications2024
A spatial perturbation framework to validate implantation of the epileptogenic zone.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- How to Recognize and Manage Missing Key Electrodes in Defining the Epileptogenic Zone.Epilepsy currents · 2026Article
- The seizure embedding map: a spatio-temporal transformer for comparing patients by ictal intracranial EEG features at scale.Journal of neural engineering · 2026Article
- A geometry aware framework enhances noninvasive mapping of whole human brain dynamics.Nature biomedical engineering · 2026Article
- Predicting surgical outcome in drug-resistant epilepsy by combining interictal biomarkers within a machine learning framework.Scientific reports · 2026Article
- Predicting Surgical Outcome in Drug-Resistant Epilepsy by Combining Interictal Biomarkers within a Machine Learning Framework.Research square · 2026Article
- The Seizure Embedding Map: A Spatio-Temporal Transformer for Comparing Patients by Ictal Intracranial EEG Features at Scale.medRxiv : the preprint server for health sciences · 2025Article
- Can electrical stimulation replace spontaneous seizures in epilepsy surgery?medRxiv : the preprint server for health sciences · 2025Article
- Localization of the Epileptogenic Zone Using Neural Spatial Volatility in Epilepsy Surgery.Neurology · 2025Observational
- Alterations in Cortical Microstructure, Morphology, and Intrinsic Local Function in Spiking Tissue in Patients With Focal Epilepsy.Neurology · 2025Article
- SEEG in 2025: progress and pending challenges in stereotaxy methods, biomarkers and radiofrequency thermocoagulation.Current opinion in neurology · 2025Review
- Simulated resections and RNS placement can optimize post-operative seizure outcomes when guided by fast ripple networks.medRxiv : the preprint server for health sciences · 2024Article
- Quantifying epileptic networks: every data point brings us a step closer to an optimized surgery.Brain communications · 2024Article
- Simulated resections and responsive neurostimulator placement can optimize postoperative seizure outcomes when guided by fast ripple networks.Brain communications · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Stereo-electroencephalography (SEEG) is the gold standard to delineate surgical targets in focal drug-resistant epilepsy. SEEG uses electrodes placed directly into the brain to identify the seizure-onset zone (SOZ). However, its major constraint is limited brain coverage, potentially leading to misidentification of the 'true' SOZ. Here, we propose a framework to assess adequate SEEG sampling by coupling epileptic biomarkers with their spatial distribution and measuring the system's response to a perturbation of this coupling. We demonstrate that the system's response is strongest in well-sampled patients when virtually removing the measured SOZ. We then introduce the spatial perturbation map, a tool that enables qualitative assessment of the implantation coverage. Probability modelling reveals a higher likelihood of well-implanted SOZs in seizure-free patients or non-seizure free patients with incomplete SOZ resections, compared to non-seizure-free patients with complete resections. This highlights the framework's value in sparing patients from unsuccessful surgeries resulting from poor SEEG coverage.
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