Evidence map›Paper›PMID 38897996›Full record

ArticleNature communications2024

Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.

Aika Iwama, Ryoji Kise, Hiroaki Akasaka, Fumiya K Sano, Hidetaka S Oshima, Asuka Inoue, Wataru Shihoya, Osamu Nureki

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aika IwamaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan.
Ryoji KiseGraduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Hiroaki AkasakaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan.ORCID 0000-0003-2118-0912
Fumiya K SanoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan.ORCID 0000-0002-8965-788X
Hidetaka S OshimaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan.ORCID 0009-0000-0341-707X
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. iaska@tohoku.ac.jp.ORCID 0000-0003-0805-4049
Wataru ShihoyaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan. wtrshh9@gmail.com.ORCID 0000-0003-4813-5740
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan. nureki@bs.s.u-tokyo.ac.jp.ORCID 0000-0003-1813-7008

Funding

Japan Agency for Medical Research and Development (AMED) 22ck0106533h0003Japan Agency for Medical Research and Development (AMED) JP22ama121002Japan Agency for Medical Research and Development (AMED) JP233fa627001MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05037
6 · The paper itself

Abstract

Pyroglutamylated RF-amide peptide (QRFP) is a peptide hormone with a C-terminal RF-amide motif. QRFP selectively activates a class A G-protein-coupled receptor (GPCR) GPR103 to exert various physiological functions such as energy metabolism and appetite regulation. Here, we report the cryo-electron microscopy structure of the QRFP26-GPR103-G

Indexed as

Cryoelectron MicroscopyReceptors, G-Protein-CoupledHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsLigandsProtein BindingIntercellular Signaling Peptides and ProteinsLigandsQRFP peptideQRFPR protein, humanReceptors, G-Protein-Coupled

Identifiers

PMID38897996
PMCPMC11187126

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.