ReviewFEMS microbiology reviews2024
Unravelling the mechanisms of antibiotic and heavy metal resistance co-selection in environmental bacteria.
Review in FEMS microbiology reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
93 citing papers in PubMed.
- Review
- Sanitation, antibiotics, and the end of the antibiotic era.Public health in practice (Oxford, England) · 2026Article
- Assessment of pathogenic traits in selected bacteria isolated from snowy environments in France and Greenland.Extremophiles : life under extreme conditions · 2026Article
- Urban-Adjacent Soils as a Global Reservoir of Toxigenic and Antimicrobial-ResistantInternational journal of molecular sciences · 2026Article
- Distribution and Genome Epidemiological Characteristics ofFoods (Basel, Switzerland) · 2026Article
- The plastisphere paradox: microplastics as engines of antimicrobial resistance and hosts for polymer degraders.World journal of microbiology & biotechnology · 2026Review
- Environmental filtering shapes biosynthetic potential and resistome of antarctic microbiomes.World journal of microbiology & biotechnology · 2026Article
- Molecular and environmental drivers of antimicrobial resistance: global epidemiology, resistome dynamics, and one health strategies.Archives of microbiology · 2026Review
- Seasonal Restructuring of Microbial Communities and Resistomes in the Shitalakshya River, Bangladesh Revealed by Shotgun Metagenomics.MicrobiologyOpen · 2026Article
- Antimicrobial resistomes in plastisphere-associated microbes over aged low-density polyethylene microplastics in the Haora River of Tripura, India.Water environment research : a research publication of the Water Environment Federation · 2026Article
- Genomic and functional characterization of Rhizobium metallidurans NS41, a heavy-metal-resistant, non-legume-associated endophyte that reduces oxidative stress in metal-exposed maize.Molecular genetics and genomics : MGG · 2026Article
- Metagenomic Insights into the Seasonal Distribution and Dissemination Risks of Biocide and Metal Resistance Genes in a Subtropical Coastal Ecosystem.Microorganisms · 2026Article
- Using auxotrophic donor strains to explore pQBR57 plasmid host range among environmental soil bacterial isolates.Microbiology (Reading, England) · 2026Article
- In-sewer microplastics drive microbial metabolic shifts toward enhanced methanogenesis.Environmental science and ecotechnology · 2026Article
- Lineage-aware comparison of extended-spectrumMicrobial genomics · 2026Article
- Genomic Diversity and Resistance Backgrounds of Enterobacteriaceae from Gulls and Coastal Environments.Genes · 2026Article
- Prolonged zinc exposure modulates biofilm metabolic activity and conjugation in Enterococcus faecalis.BMC microbiology · 2026Article
- Genome-based insights into metal co-resistance in Amazonian mercury-resistant bacteria: ecological lifestyle and biosafety implications for bioremediation.Microbiology spectrum · 2026Article
- Beyond the germ: Rethinking implant-related infections as a host-microbiota-biomaterial ecosystem.Biofilm · 2026Review
- Metagenomic analysis of antimicrobial resistance genes in domestic canines.One health (Amsterdam, Netherlands) · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The co-selective pressure of heavy metals is a contributor to the dissemination and persistence of antibiotic resistance genes in environmental reservoirs. The overlapping range of antibiotic and metal contamination and similarities in their resistance mechanisms point to an intertwined evolutionary history. Metal resistance genes are known to be genetically linked to antibiotic resistance genes, with plasmids, transposons, and integrons involved in the assembly and horizontal transfer of the resistance elements. Models of co-selection between metals and antibiotics have been proposed, however, the molecular aspects of these phenomena are in many cases not defined or quantified and the importance of specific metals, environments, bacterial taxa, mobile genetic elements, and other abiotic or biotic conditions are not clear. Co-resistance is often suggested as a dominant mechanism, but interpretations are beset with correlational bias. Proof of principle examples of cross-resistance and co-regulation has been described but more in-depth characterizations are needed, using methodologies that confirm the functional expression of resistance genes and that connect genes with specific bacterial hosts. Here, we comprehensively evaluate the recent evidence for different models of co-selection from pure culture and metagenomic studies in environmental contexts and we highlight outstanding questions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.