Evidence map›Paper›PMID 38897729›Full record

ReviewSexually transmitted infections2024

Missed opportunities for guidance on sexually transmitted infection services: a global review of national HIV PrEP guidance.

Erica Spielman, Maeve B Mello, Robin Schaefer, Jason Ong, Heather-Marie A Schmidt, Mary Henderson, Pietro Vinti, Mateo Prochazka, Niklas Luhmann, Rachel Baggaley

Abstract readReview
In one paragraph

Review in Sexually transmitted infections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Extensively drug-resistant (XDR)Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erica SpielmanGlobal HIV, Hepatitis, and STIs Programmes, World Health Organization, Geneva, Switzerland spielmane@who.int.ORCID 0000-0001-6380-0505
Maeve B MelloGlobal HIV, Hepatitis, and STIs Programmes, World Health Organization, Geneva, Switzerland.
Robin SchaeferForum for Collaborative Research, Berkeley, California, USA.ORCID 0000-0003-4733-4692
Jason OngCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Heather-Marie A SchmidtGlobal HIV, Hepatitis, and STIs Programmes, World Health Organization, Geneva, Switzerland.
Mary HendersonIndependent consultant, Riverside, Connecticut, USA.
Pietro VintiJoint Infectious Diseases Unit, World Health Organization Regional Office for Europe, Copenhagen, Capital Region, Denmark.
Mateo ProchazkaGlobal HIV, Hepatitis, and STIs Programmes, World Health Organization, Geneva, Switzerland.
Niklas LuhmannGlobal HIV, Hepatitis, and STIs Programmes, World Health Organization, Geneva, Switzerland.
Rachel BaggaleyGlobal HIV, Hepatitis, and STIs Programmes, World Health Organization, Geneva, Switzerland.

Funding

World Health Organization 001
6 · The paper itself

Abstract

objectivesPeople who use or would benefit from pre-exposure prophylaxis (PrEP) for HIV infection are disproportionately affected by sexually transmitted infections (STIs). Integrating STI services when offering PrEP fosters synergies and efficiencies in response to HIV/STI and promotes people-centred care. Including guidance on STI interventions for people on PrEP may facilitate implementation and uptake. We conducted a global review of national PrEP guidance documents and analysed the inclusion of recommendations for the provision of STI services by country level of income.

methodsWe searched national PrEP guidance documents published by WHO Member States through the WHO, the Joint United Nations Programme on HIV/AIDS (UNAIDS) databases, the

resultsOf the 113 national PrEP guidance documents retrieved, STIs were mentioned in 77% (90/117). Viral hepatitis B testing and vaccination were recommended by most high-income countries (HICs) and low-income and middle-income countries (LMICs). Recommendation for syphilis testing was prominent in HICs (91%) and moderately noted in LMICs (68%). Gonorrhoea and chlamydia testing was recommended frequently in HICs (88%) and 42% in LMICs. However, the review noted that, to a much lesser extent, specific type of testing for these pathogens was mentioned. Recommendation for quarterly STI testing for syphilis, gonorrhoea and chlamydia was ubiquitous, while the need to offer STI partner services was rarely mentioned.

conclusionsPrEP services offer an opportunity for improved and expanded STI services, increasing person-centred care and addressing STI epidemics alongside HIV. Our review highlights the strengths and gaps in incorporating critical STI interventions into national PrEP normative guidance. Addressing these gaps through a stepwise approach and increasing targeted testing and partner services can help improve quality of care and support an effective response to HIV and other STIs.

Indexed as

HIV InfectionsPre-Exposure ProphylaxisSexually Transmitted DiseasesGlobal HealthHumansPractice Guidelines as TopicPre-Exposure ProphylaxisREPRODUCTIVE HEALTHSEXUAL HEALTH

Identifiers

PMID38897729
PMCPMC11347216

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.