Evidence map›Paper›PMID 38897626›Full record

ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2024

Safety and efficacy of histotripsy delivery through overlying gas-filled small bowel in an ex vivo swine model.

Meridith A Kisting, James K White, Sarvesh Periyasamy, Ayca Z Kutlu, Adrienne L Kisting, Xiaofei Zhang, Lu Mao, Paul F Laeseke, Martin G Wagner, Eli Vlaisavljevich and 2 more

Abstract read
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In one paragraph

Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Histotripsy of the hepatic capsule and the gastric wall: acute treatment effects in a swine model.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meridith A KistingDepartments of Radiology, University of Wisconsin, Madison, WI, USA.
James K WhiteDepartments of Radiology, University of Wisconsin, Madison, WI, USA.
Sarvesh PeriyasamyDepartment of Radiology, Stanford University, Stanford, CA, USA.
Ayca Z KutluDepartments of Radiology, University of Wisconsin, Madison, WI, USA.
Adrienne L KistingDepartments of Radiology, University of Wisconsin, Madison, WI, USA.
Xiaofei ZhangSchool of Medicine Department of Pathology, NY University, Long Island, NY, USA.
Lu MaoDepartments of Biostatistics, University of Wisconsin, Madison, WI, USA.
Paul F LaesekeDepartments of Radiology, University of Wisconsin, Madison, WI, USA.
Martin G WagnerDepartments of Radiology, University of Wisconsin, Madison, WI, USA.
Eli VlaisavljevichDepartment of Biomedical Engineering, VA Tech, Blacksburg, VA, USA.
Fred T LeeDepartments of Radiology, University of Wisconsin, Madison, WI, USA.
Timothy J ZiemlewiczDepartments of Radiology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-7033-1062

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Developing Methods for Precise, Safe and Target-location Specific Histotripsy of Liver TumorsR01CA262474 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ZIEMLEWICZ, TIMOTHY J · 2021 to 2025
$2.4M
NCATS NIH HHS UL1 TR002373NCI NIH HHS R01 CA262474
6 · The paper itself

Abstract

purposeTo evaluate the safety and efficacy of performing histotripsy through overlying gas-filled bowel in an

methodsAn

resultsAll histotripsy treatments through partial blockage were successful (24/24). No visible or microscopic damage was observed to intervening bowel. Partial blockage resulted in a small increase in treatment volume compared to controls (

conclusionHistotripsy has the potential to be applied through partial gas blockage of the therapeutic beam path, as shown by this

Indexed as

Intestine, SmallAnimalsGasesSwineGasesex vivo modelfocused ultrasoundgas blockageHistotripsysmall bowel

Identifiers

PMID38897626
PMCPMC11224713

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.