Evidence map›Paper›PMID 38897621›Full record

ArticleBMJ paediatrics open2024

Association of different doses of antenatal corticosteroids exposure with early major outcomes and early weight loss percentage in extremely preterm infants or extremely low birthweight infants: a multicentre cohort study.

Shuaijun Li, Qi Feng, Xiaofang Huang, Xiuying Tian, Ying Zhou, Yong Ji, Shufen Zhai, Wei Guo, Rongxiu Zheng, Haijun Wang

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ paediatrics open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06082414 (Systemic Management in Extremely Preterm and Extremely Low Birth Weight Infants), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06082414 completednot on this map

Systemic Management in Extremely Preterm and Extremely Low Birth Weight Infants

TypeobservationalSponsorPeking UniversityRan2019 to 2020Enrolled1,200ConditionsBronchopulmonary Dysplasia, DeathArmsno interventions
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuaijun LiDepartment of Maternal and Child Health, School of Public Health, Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-8728-6811
Qi Feng *Department of Pediatrics, Peking University First Hospital, Beijing, China fengqizf@126.com.
Xiaofang HuangDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Xiuying TianDepartment of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China.
Ying ZhouDepartment of Pediatrics, Peking University Third Hospital, Beijing, China.
Yong JiNeonatal Intensive Care Unit, Children's Hospital of Shanxi, Taiyuan, China.
Shufen ZhaiDepartment of Neonatology, Handan Central Hospital, Handan, China.
Wei GuoDepartment of Neonatology, Xingtai People's Hospital, Xingtai, China.
Rongxiu ZhengDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China.
Haijun Wang *Department of Maternal and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Peking University School of Public Health, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the dose-dependent associations between antenatal corticosteroids (ANS) exposure and the rates of major morbidities, and the early weight loss percentage (EWLP) in hospital among extremely preterm infants (EPI) or extremely low birthweight infants (ELBWI).

methodsA multicentre, retrospective cohort study of EPI or ELBWI born between 2017 and 2018 was conducted. Infants were classified into no ANS, partial ANS and complete ANS exposure group; three subgroups were generated by gestational age and birth weight. Multiple logistic regression and multiple linear regression were performed.

resultsThere were 725 infants included from 32 centres. Among no ANS, partial ANS and complete ANS exposure, there were significant differences in the proportions of bronchopulmonary dysplasia (BPD) (24.5%, 25.4% and 16.1%), necrotising enterocolitis (NEC) (6.7%, 2.0% and 2.0%) and death (29.6%, 18.5% and 13.5%), and insignificant differences in the proportions of intraventricular haemorrhage (IVH) (12.5%, 13.2% and 12.2%), and extrauterine growth restriction (EUGR) (50.0%, 56.6% and 59.5%). In the logistic regression, compared with no ANS exposure, complete ANS reduced the risk of BPD (OR 0.58, 95% CI 0.37 to 0.91), NEC (OR 0.21, 95% CI 0.08 to 0.57) and death (OR 0.36, 95% CI 0.23 to 0.56), and partial ANS reduced the risk of NEC (OR 0.23, 95% CI 0.07 to 0.72) and death (OR 0.54, 95% CI 0.34 to 0.87). Compared with partial ANS exposure, complete ANS decreased the risk of BPD (OR 0.58, 95% CI 0.37 to 0.91). There were insignificant associations between ANS exposure and IVH, EUGR. In the multiple linear regression, partial and complete ANS exposure increased EWLP only in the ≥28 weeks (w) and <1000 g subgroup (p<0.05).

conclusionsDifferent doses of ANS (dexamethasone) exposure were protectively associated with BPD, NEC, death in hospital, but not EUGR at discharge among EPI or ELBWI. Beneficial dose-dependent associations between ANS (dexamethasone) exposure and BPD existed. ANS exposure increased EWLP only in the ≥28 w and<1000 g subgroup. ANS administration, especially complete ANS, is encouraged before preterm birth. TRIAL REGISTRATION NUMBER: NCT06082414.

Indexed as

Infant, Extremely Low Birth WeightInfant, Extremely PrematureWeight LossAdrenal Cortex HormonesBronchopulmonary DysplasiaDose-Response Relationship, DrugEnterocolitis, NecrotizingFemaleGestational AgeHumansInfant, NewbornInfant, Premature, DiseasesMalePregnancyRetrospective StudiesAdrenal Cortex Hormonesgrowthmortalityneonatology

Identifiers

PMID38897621
PMCPMC11191796

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.