Evidence map›Paper›PMID 38897570›Full record

ArticleThe Journal of biological chemistry2024

Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure.

Jingjing Wang, Bo Xiao, Eiki Kimura, Maureen Mongan, Wei-Wen Hsu, Mario Medvedovic, Alvaro Puga, Ying Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingjing WangDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.
Bo XiaoDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.
Eiki KimuraDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.
Maureen MonganDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.
Wei-Wen HsuDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.
Mario MedvedovicDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.
Alvaro PugaDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.
Ying XiaDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA. Electronic address: ying.xia@uc.edu.

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Gene-environment interactions in epithelial morphogenesisR01HD098106 · NICHD · UNIVERSITY OF CINCINNATI · PI XIA, YING · 2019 to 2023
$2.3M
Signaling mechanisms of gene-environment interactions in female reproductiveR21ES033342 · NIEHS · UNIVERSITY OF CINCINNATI · PI XIA, YING · 2022 to 2023
$446k
NICHD NIH HHS R01 HD098106NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R21 ES033342
6 · The paper itself

Abstract

Aberrant regulation of signal transduction pathways can adversely derail biological processes for tissue development. One such process is the embryonic eyelid closure that is dependent on the mitogen-activated protein kinase kinase kinase 1 (MAP3K1). Map3k1 KO in mice results in defective eyelid closure and an autosomal recessive eye-open at birth phenotype. We have shown that in utero exposure to dioxin, a persistent environmental toxicant, induces the same eye defect in Map3k1

Indexed as

DioxinsErbB ReceptorsMAP Kinase Kinase Kinase 1Receptors, Aryl HydrocarbonAnimalsBasic Helix-Loop-Helix ProteinsEyelidsFemaleGene-Environment InteractionJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemMiceMice, KnockoutReceptor Cross-TalkSignal TransductionAhr protein, mouseBasic Helix-Loop-Helix ProteinsDioxinsEGFR protein, mouseErbB ReceptorsJNK Mitogen-Activated Protein KinasesMap3k1 protein, mouseMAP Kinase Kinase Kinase 1Receptors, Aryl HydrocarbonAHRdevelopmental tissue closuredioxinEGFRepithelial morphogenesisgene-environment interactionsthe S1PR-MAP3K1-JNK pathway

Identifiers

PMID38897570
PMCPMC11294703

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.