Evidence map›Paper›PMID 38897385›Full record

SynthesisAdvances in nutrition (Bethesda, Md.)2024

The Effect of Time-Restricted Eating Combined with Exercise on Body Composition and Metabolic Health: A Systematic Review and Meta-Analysis.

Zihan Dai, Kewen Wan, Masashi Miyashita, Robin Sze-Tak Ho, Chen Zheng, Eric Tsz-Chun Poon, Stephen Heung-Sang Wong

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Advances in nutrition (Bethesda, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 10 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zihan DaiDepartment of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China.
Kewen WanDepartment of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China; Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Hong Kong, China.
Masashi MiyashitaDepartment of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China; Faculty of Sport Sciences, Waseda University, Saitama, Japan; School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, United Kingdom.
Robin Sze-Tak HoDepartment of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China.
Chen ZhengDepartment of Health and Physical Education, The Education University of Hong Kong, Hong Kong, China.
Eric Tsz-Chun PoonDepartment of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China.
Stephen Heung-Sang WongDepartment of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: hsswong@cuhk.edu.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTime-restricted eating (TRE) is increasingly popular, but its benefits in combination with exercise still need to be determined.

objectivesThis systematic review and meta-analysis aimed to evaluate the efficacy of TRE combined with exercise compared with control diet with exercise in improving the body composition and metabolic health of adults.

methodsFive electronic databases were searched for relevant studies. Randomized controlled trials (RCTs) examining the effect of TRE combined with exercise on body composition and metabolic health in adults were included. All results in the meta-analysis are reported as mean difference (MD) with 95% confidence interval (CI). Study quality was assessed using the revised Cochrane Risk of Bias Tool and Grading of Recommendations Assessment, Development, and Evaluation assessment.

resultsIn total, 19 RCTs comprising 568 participants were included in this systematic review and meta-analysis. TRE combined with exercise likely reduced the participants' body mass (MD: -1.86 kg; 95% CI: -2.75, -0.97 kg) and fat mass (MD: -1.52 kg; 95% CI: -2.07, -0.97 kg) when compared with the control diet with exercise. In terms of metabolic health, the TRE combined with exercise group likely reduced triglycerides (MD: -13.38 mg/dL, 95% CI: -21.22, -5.54 mg/dL) and may result in a reduction in low-density lipoprotein (MD: -8.52 mg/dL; 95% CI: -11.72, -5.33 mg/dL) and a large reduction in leptin (MD: -0.67 ng/mL; 95% CI: -1.02, -0.33 ng/mL). However, TRE plus exercise exhibited no additional benefit on the glucose profile, including fasting glucose and insulin, and other lipid profiles, including total cholesterol and high-density lipoprotein concentrations, compared with the control group.

conclusionsCombining TRE with exercise may be more effective in reducing body weight and fat mass and improving lipid profile than control diet with exercise. Implementing this approach may benefit individuals aiming to achieve weight loss and enhance their metabolic well-being. This study was registered in PROSPERO as CRD42022353834.

Indexed as

Body CompositionExerciseBody Mass IndexDietFastingHumansRandomized Controlled Trials as TopicTriglyceridesTriglyceridesexerciseintermittent fastingmetabolic healthnutritiontime-restricted eating

Identifiers

PMID38897385
PMCPMC11301358

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.