Evidence map›Paper›PMID 38897028›Full record

ArticleBiomaterials2024

3D electronic implants in subretinal space: Long-term follow-up in rodents.

Mohajeet B Bhuckory, Bing-Yi Wang, Zhijie C Chen, Andrew Shin, Davis Pham-Howard, Sarthak Shah, Nicharee Monkongpitukkul, Ludwig Galambos, Theodore Kamins, Keith Mathieson and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Neural Vision Restoration in Ophthalmology.Annals of biomedical engineering · 2026
    Review
  2. Review
  3. Article
  4. Application of Silicone in Ophthalmology: A Review.Materials (Basel, Switzerland) · 2024
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mohajeet B BhuckoryDepartment of Ophthalmology, Stanford University, Stanford, CA, USA; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA. Electronic address: bhuckory@stanford.edu.
Bing-Yi WangDepartment of Physics, Stanford University, Stanford, CA, USA.
Zhijie C ChenDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Andrew ShinDepartment of Material Science, Stanford University, Stanford, CA, USA.
Davis Pham-HowardDepartment of Ophthalmology, Stanford University, Stanford, CA, USA; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Sarthak ShahHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Nicharee MonkongpitukkulDepartment of Ophthalmology, Stanford University, Stanford, CA, USA; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Ludwig GalambosHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.
Theodore KaminsHansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA; Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
Keith MathiesonDepartment of Physics, Institute of Photonics, University of Strathclyde, Glasgow, Scotland, UK.
Daniel PalankerDepartment of Ophthalmology, Stanford University, Stanford, CA, USA; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, USA.

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Photovoltaic Subretinal Prosthesis with High Pixel DensityR01EY027786 · NEI · STANFORD UNIVERSITY · PI PALANKER, DANIEL V · 2017 to 2021
$3.3M
Electronic photoreceptors for restoration of sight in retinal degenerationR01EY035227 · NEI · STANFORD UNIVERSITY · PI DANIEL V PALANKER · 2023 to 2026
$2.7M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY027786NEI NIH HHS R01 EY035227
6 · The paper itself

Abstract

Clinical results with photovoltaic subretinal prosthesis (PRIMA) demonstrated restoration of sight via electrical stimulation of the interneurons in degenerated retina, with resolution matching the 100 μm pixel size. Since scaling the pixels below 75 μm in the current bipolar planar geometry will significantly limit the penetration depth of the electric field and increase stimulation threshold, we explore the possibility of using smaller pixels based on a novel 3-dimensional honeycomb-shaped design. We assessed the long-term biocompatibility and stability of these arrays in rats by investigating the anatomical integration of the retina with flat and 3D implants and response to electrical stimulation over lifetime - up to 32-36 weeks post-implantation in aged rats. With both flat and 3D implants, signals elicited in the visual cortex decreased after the day of implantation by more than 3-fold, and gradually recovered over the next 12-16 weeks. With 25 μm high honeycomb walls, the majority of bipolar cells migrate into the wells, while amacrine and ganglion cells remain above the cavities, which is essential for selective network-mediated stimulation of the retina. Retinal thickness and full-field stimulation threshold with 40 μm-wide honeycomb pixels were comparable to those with planar devices - 0.05 mW/mm

Indexed as

RetinaVisual ProsthesisAnimalsElectric StimulationElectrodes, ImplantedFollow-Up StudiesRatsRats, Long-EvansPhotoreceptor degenerationPhotovoltaic retinal prosthesisSubretinal surgeryVision restoration

Identifiers

PMID38897028
PMCPMC11298295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.